Gene
akr1a1b
- ID
- ZDB-GENE-050417-118
- Name
- aldo-keto reductase family 1, member A1b (aldehyde reductase)
- Symbol
- akr1a1b Nomenclature History
- Previous Names
-
- zgc:110225 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables aldo-keto reductase (NADPH) activity. Involved in glucose homeostasis and regulation of gluconeogenesis. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; immune system; liver; and muscle. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025507Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025508Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| uh8 | Allele with one insertion | Exon 4 | Unknown | CRISPR | |
| uh9 | Allele with one deletion | Exon 4 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018170 | Aldo/keto reductase, conserved site |
| Domain | IPR023210 | NADP-dependent oxidoreductase domain |
| Family | IPR020471 | Aldo-keto reductase |
| Family | IPR044481 | Aldo-keto reductase family 1 member A1 |
| Homologous_superfamily | IPR036812 | NADP-dependent oxidoreductase domain superfamily |
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Domain Details Per Protein
| Protein | Length | Aldo-keto reductase | Aldo/keto reductase, conserved site | Aldo-keto reductase family 1 member A1 | NADP-dependent oxidoreductase domain | NADP-dependent oxidoreductase domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q568L5
|
324 | |||||
|
UniProtKB:A0A8M2BDN5
|
351 | |||||
|
UniProtKB:A0A8M2BDV8
|
326 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
akr1a1b-201
(1)
|
Ensembl | 754 nt | ||
| mRNA |
akr1a1b-202
(1)
|
Ensembl | 1,091 nt | ||
| mRNA |
akr1a1b-203
(1)
|
Ensembl | 910 nt | ||
| mRNA |
akr1a1b-204
(1)
|
Ensembl | 760 nt | ||
| mRNA |
akr1a1b-205
(1)
|
Ensembl | 1,182 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-akr1a1b | polyclonal | Guinea pig |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-175H18 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7154417 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110225 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174295 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017640 (1) | 1160 nt | ||
| Genomic | GenBank:AL807381 (1) | 230718 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDN5 (1) | 351 aa |
- Li, C., Wu, Y., Li, H., Wang, H., Liu, J.X. (2022) Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Fish physiology and biochemistry. 48(6):1571-1586
- Li, X., Schmöhl, F., Qi, H., Bennewitz, K., Tabler, C.T., Poschet, G., Hell, R., Volk, N., Poth, T., Hausser, I., Morgenstern, J., Fleming, T., Nawroth, P.P., Kroll, J. (2020) Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. iScience. 23:101763
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hassanin, A., Kaminishi, Y., Itakura, T. (2017) Characterization of Tilapia (Oreochromis niloticus) aldehyde reductase (AKR1A1) gene, promoter and expression pattern in benzo-a-pyrene exposed fish. Toxicology mechanisms and methods. 27(1):36-44
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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