Gene

eif2ak3

ID
ZDB-GENE-050414-2
Name
eukaryotic translation initiation factor 2-alpha kinase 3
Symbol
eif2ak3 Nomenclature History
Previous Names
  • PEK (1)
  • PERK (1)
  • zgc:152949
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have eukaryotic translation initiation factor 2alpha kinase activity. Involved in response to endoplasmic reticulum stress and response to hypoxia. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Is expressed in brain and liver. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With eif2ak3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Wolcott-Rallison syndrome Alliance Wolcott-Rallison syndrome 226980
Associated With eif2ak3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Quinoprotein alcohol dehydrogenase-like superfamily Serine/threonine-protein kinase, active site WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:B8JI14 1099
UniProtKB:Q0P4F2 323
UniProtKB:F1Q9L5 323
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations