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ZIRC
ZFIN ID: ZDB-GENE-050309-23
Gene Name: integrin, alpha 6a
Gene Symbol: itga6a    Nomenclature History

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Previous Names: itga6, fb80g02, im:6897425, si:dkey-32o22.1, wu:fb80g02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Involved in skeletal muscle tissue development. Predicted to localize to the integrin complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Is expressed in several structures, including axial chorda mesoderm; hypodermis; retina; solid lens vesicle; and trunk. Orthologous to human ITGA6 (integrin subunit alpha 6).
Genome Resources: Alliance (1),  Gene:503893 (1),  Ensembl(GRCz11):ENSDARG00000042282 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18258 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21422 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-itga6a N/A 1
    MO2-itga6a N/A 1
    DISEASE ASSOCIATED WITH itga6a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    junctional epidermolysis bullosa with pyloric atresia Alliance Epidermolysis bullosa, junctional, with pyloric stenosis 226730
    DISEASE ASSOCIATED WITH itga6a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process skeletal muscle tissue development (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 6)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cu469503.1-201 (1)    Ensembl 1274
    itga6a-201 (1)    Ensembl 3231
    itga6a-202 (1)    Ensembl 4057
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-itga6a polyclonal Guinea pig 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itga6a No data available
    MARKER RELATIONSHIPS
    itga6a Contained in: [BAC] CH211-245G15 (1) (order this), DKEY-251J19 (1) (order this)
    itga6a Encodes: [EST] fb80g02, IMAGE:6897425 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005167409 (1) 3505 bp
    Genomic GenBank:CU469503 (1) 166759 bp
    Select Tool
    Polypeptide UniProtKB:A8WHQ8 (1) 1092 aa
    Sequence Clusters UniGene:117274 (1)
    Sequence Information (all 31)
    ORTHOLOGY for itga6a ( Chr: 9 )
    CITATIONS (22)