wars2

ID

ZDB-GENE-050306-26

Name

tryptophanyl tRNA synthetase 2, mitochondrial

Symbol

wars2 Nomenclature History

Previous Names

zgc:110828 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable tryptophan-tRNA ligase activity. Predicted to be involved in mitochondrial tryptophanyl-tRNA aminoacylation. Predicted to be active in mitochondrial matrix. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907795 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Wang et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures	617710
		Parkinsonism-dystonia 3, childhood-onset	619738

Associated With wars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Family	IPR002305	Aminoacyl-tRNA synthetase, class Ic
Family	IPR002306	Tryptophan-tRNA ligase
Family	IPR024109	Tryptophan-tRNA ligase, bacterial-type
Family	IPR050203	Tryptophan--tRNA ligase
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q5CZN2	InterPro	364
UniProtKB:A0AB32U194	InterPro	290
UniProtKB:A0AC58GDX5	InterPro	278
UniProtKB:A0AC58GDX6	InterPro	290
UniProtKB:A0AC58GDY3	InterPro	290
UniProtKB:A0AC58GDY4	InterPro	409