Gene
crebbpb
- ID
- ZDB-GENE-050302-102
- Name
- CREB binding protein b
- Symbol
- crebbpb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Predicted to be involved in histone acetylation and regulation of transcription, DNA-templated. Predicted to localize to histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Is expressed in somite. Orthologous to human CREBBP (CREB binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150488 (1 image)
- dq017638 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Rubinstein-Taybi syndrome | Alliance | Rubinstein-Taybi syndrome 1 | 180849 |
| Menke-Hennekam syndrome 1 | 618332 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR000197 | Zinc finger, TAZ-type |
| Domain | IPR000433 | Zinc finger, ZZ-type |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR003101 | Coactivator CBP, KIX domain |
| Domain | IPR010303 | CREB-binding protein/p300, atypical RING domain |
| Domain | IPR014744 | Nuclear receptor coactivator, CREB-bp-like, interlocking |
| Domain | IPR031162 | CBP/p300-type histone acetyltransferase domain |
| Family | IPR013178 | Histone acetyltransferase Rtt109/CBP |
| Homologous_superfamily | IPR009110 | Nuclear receptor coactivator, interlocking |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR035898 | TAZ domain superfamily |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR036529 | Coactivator CBP, KIX domain superfamily |
| Homologous_superfamily | IPR038547 | CBP/p300, atypical RING domain superfamily |
| Homologous_superfamily | IPR043145 | Zinc finger, ZZ-type superfamily |
Domain Details Per Protein
| Protein | Length | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | CBP/p300, atypical RING domain superfamily | CBP/p300-type histone acetyltransferase domain | Coactivator CBP, KIX domain | Coactivator CBP, KIX domain superfamily | CREB-binding protein/p300, atypical RING domain | Histone acetyltransferase Rtt109/CBP | Nuclear receptor coactivator, CREB-bp-like, interlocking | Nuclear receptor coactivator, interlocking | TAZ domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, TAZ-type | Zinc finger, ZZ-type | Zinc finger, ZZ-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PUL2
|
2431 | ||||||||||||||||
|
UniProtKB:A0A8M9PNF9
|
2420 | ||||||||||||||||
|
UniProtKB:A0A8M3B0Q0
|
2435 | ||||||||||||||||
|
UniProtKB:A0A8M3AXR2
|
2424 | ||||||||||||||||
|
UniProtKB:A0A8M9Q1N8
|
2321 | ||||||||||||||||
|
UniProtKB:A0A8M3AQ93
|
2325 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
crebbpb-201
(1)
|
Ensembl | 9,022 nt | ||
| mRNA |
crebbpb-202
(1)
|
Ensembl | 12,266 nt |
Interactions and Pathways
No data available
Plasmids
No data available