ZFIN ID: ZDB-GENE-050227-4
Gene Name: regulatory factor X, 2 (influences HLA class II expression)
Gene Symbol: rfx2    Nomenclature History

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Previous Names: cb133 (1), cb7 (1), sb:cb133, sb:cb7, wu:fd20b11, zgc:91808

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in Kupffer's vesicle development and determination of left/right symmetry. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; mesoderm; neural plate; neural tube; and pronephros. Orthologous to human RFX2 (regulatory factor X2).
Genome Resources: Alliance (1),  Gene:503590 (1),  Ensembl(GRCz11):ENSDARG00000013575 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct81Gt Transgenic Insertion Unknown Unknown DNA
la010683Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la016289Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026392Tg Transgenic Insertion Unknown Unknown DNA
    sa14019 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21260 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31644 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rfx2 N/A 3
    MO2-rfx2 N/A 1
    MO3-rfx2 N/A 1
    DISEASE ASSOCIATED WITH rfx2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rfx2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component cytoplasm (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rfx2-201 (1)    Ensembl 3935
    rfx2-202 (1)    Ensembl 639
    rfx2-203 (1)    Ensembl 913
    rfx2-204 (1)    Ensembl 675
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rfx2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:rfx2-HA) hsp70l rfx2 Danio rerio 1 2
    MARKER RELATIONSHIPS
    rfx2 Contained in: [BAC] CH211-275D22 (1), DKEY-240A9 (1) (order this)
    rfx2 Encodes: [EST] cb7 (order this), cb133 (1) (order this), fd20b11
    [cDNA] MGC:91808 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001013278 (1) 3689 nt
    Genomic GenBank:BX664738 (1) 180024 nt
    Select Tool
    Polypeptide UniProtKB:Q5EAP5 (1) 734 aa
    Sequence Information (all 21)
    ORTHOLOGY for rfx2 ( Chr: 8 )
    CITATIONS (50)