Gene
nkx2.2b
- ID
- ZDB-GENE-050217-3
- Name
- NK2 homeobox 2b
- Symbol
- nkx2.2b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within floor plate formation and ventral spinal cord interneuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; prechordal plate; presumptive ectoderm; primary interneuron; and trunk. Orthologous to human NKX2-2 (NK2 homeobox 2) and NKX2-8 (NK2 homeobox 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7162914 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-nkx2.2b | N/A | Schafer et al., 2007 |
| MO2-nkx2.2b | N/A | Yang et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox NK-like transcription regulators | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5BJA8 | InterPro | 237 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nkx2.2b-201
(1)
|
Ensembl | 1,634 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(nkx2.2b:Cre-mCherry-NLS) |
|
| 1 | Böhm et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-165F9 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-50F5 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7162914 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:113384 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192250 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007782 (1) | 1584 nt | ||
| Genomic | GenBank:BX663521 (2) | 179633 nt | ||
| Polypeptide | UniProtKB:Q5BJA8 (1) | 237 aa |
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Böhm, U.L., Kimura, Y., Kawashima, T., Ahrens, M.B., Higashijima, S.I., Engert, F., Cohen, A.E. (2022) Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish. Neuron. 110(7):1211-1222.e4
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Truong, M.E., Bilekova, S., Choksi, S.P., Li, W., Bugaj, L.J., Xu, K., Reiter, J.F. (2021) Vertebrate cells differentially interpret ciliary and extraciliary cAMP. Cell. 184(11):2911-2926.e18
- Tschaikner, P., Regele, D., Röck, R., Salvenmoser, W., Meyer, D., Bouvier, M., Geley, S., Stefan, E., Aanstad, P. (2021) Feedback Control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish. Development (Cambridge, England). 148(4):
- Granadeiro, L., Dirks, R.P., Ortiz-Delgado, J.B., Gavaia, P.J., Sarasquete, C., Laizé, V., Cancela, M.L., Fernández, I. (2019) Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner - From molecular mechanisms to environmental concerns. Ecotoxicology and environmental safety. 181:559-571
- Klatt Shaw, D., Gunther, D., Jurynec, M.J., Chagovetz, A.A., Ritchie, E., Grunwald, D.J. (2018) Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling. Developmental Cell. 45(4):512-525.e5
- Han, Y., Xiong, Y., Shi, X., Wu, J., Zhao, Y., Jiang, J. (2017) Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system. PLoS Biology. 15:e2002063
- Lu, H., Galeano, M.C.R., Ott, E., Kaeslin, G., Kausalya, P.J., Kramer, C., Ortiz-Brüchle, N., Hilger, N., Metzis, V., Hiersche, M., Tay, S.Y., Tunningley, R., Vij, S., Courtney, A.D., Whittle, B., Wühl, E., Vester, U., Hartleben, B., Neuber, S., Frank, V., Little, M.H., Epting, D., Papathanasiou, P., Perkins, A.C., Wright, G.D., Hunziker, W., Gee, H.Y., Otto, E.A., Zerres, K., Hildebrandt, F., Roy, S., Wicking, C., Bergmann, C. (2017) Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nature Genetics. 49:1025–1034
- Pan, C., Xiong, Y., Lv, X., Xia, Y., Zhang, S., Chen, H., Fan, J., Wu, W., Liu, F., Wu, H., Zhou, Z., Zhang, L., Zhao, Y. (2017) UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. EMBO reports. 18:1922-1934
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