Gene

hif1al2

ID

ZDB-GENE-050211-2

Name

hypoxia inducible factor 1 subunit alpha, like 2

Symbol

hif1al2 Nomenclature History

Previous Names

hif1al (1)
Hif2a (1)
HIF3B (1)
zgc:112119

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to hypoxia and regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin. Is expressed in several structures, including digestive system; gill; head; heart; and pleuroperitoneal region.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hif1al2 Human Ortholog

No data available

Associated With hif1al2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000014	PAS domain
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR013767	PAS fold
Domain	IPR014887	HIF-1 alpha, C-terminal transactivation domain
Domain	IPR021537	Hypoxia-inducible factor, alpha subunit-like
Homologous_superfamily	IPR035965	PAS domain superfamily
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily
Repeat	IPR001610	PAC motif