Gene
prkar1aa
- ID
- ZDB-GENE-050116-2
- Name
- protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a
- Symbol
- prkar1aa Nomenclature History
- Previous Names
-
- prkar1a
- im:7047729
- zgc:92515
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cGMP-mediated signaling. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Is expressed in early embryonic cell; immature eye; neural tube; and somite. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Kotani et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kotani et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrodysostosis | Alliance | Acrodysostosis 1, with or without hormone resistance | 101800 |
| Carney complex | Alliance | Carney complex, type 1 | 160980 |
| primary pigmented nodular adrenocortical disease 1 | Alliance | Pigmented nodular adrenocortical disease, primary, 1 | 610489 |
| Adrenocortical tumor, somatic | |||
| Myxoma, intracardiac | 255960 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR003117 | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain |
| Family | IPR012198 | cAMP-dependent protein kinase regulatory subunit |
| Family | IPR050503 | cAMP-dependent kinase regulatory chain |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | cAMP-dependent kinase regulatory chain | cAMP-dependent protein kinase regulatory subunit | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5I0F6
|
379 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkar1aa-201
(1)
|
Ensembl | 3,964 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-prkar1aa | polyclonal | Mouse |
|
1 |
Plasmids
No data available