Gene

slc6a9

ID
ZDB-GENE-050105-3
Name
solute carrier family 6 member 9
Symbol
slc6a9 Nomenclature History
Previous Names
  • glyt1 (2)
  • sho
  • shocked
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Enables glycine transmembrane transporter activity. Acts upstream of or within several processes, including glycine transport; inhibitory postsynaptic potential; and regulation of glycinergic synaptic transmission. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in fourth ventricle; hindbrain; neural rod; optic tectum; and spinal cord. Used to study idiopathic scoliosis. Orthologous to human SLC6A9 (solute carrier family 6 member 9).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
chk1Allele with one deletionUnknownUnknownCRISPR
la023611TgTransgenic insertionUnknownUnknownDNA
sa19804Allele with one point mutationUnknownPremature StopENU
sa19805Allele with one point mutationUnknownPremature StopENU
sa39868Allele with one point mutationUnknownPremature StopENU
ta51eunknownUnknownUnknownENU
ta229gunknownUnknownUnknownENU
te301unknownUnknownUnknownENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-slc6a9Wang et al., 2023
MO1-slc6a9N/A (2)
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Human Disease
Associated With slc6a9 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Glycine encephalopathy with normal serum glycine 617301
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Associated With slc6a9 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000175 Sodium:neurotransmitter symporter
Family IPR003028 Sodium:neurotransmitter symporter, glycine, type 1
Homologous_superfamily IPR037272 Sodium:neurotransmitter symporter superfamily
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Domain Details Per Protein
Protein Additional Resources Length Sodium:neurotransmitter symporter Sodium:neurotransmitter symporter, glycine, type 1 Sodium:neurotransmitter symporter superfamily
UniProtKB:Q4FIV7 InterPro 649
UniProtKB:Q4FIV5 InterPro 644
UniProtKB:Q4FIV6 InterPro 653
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA slc6a9-201 (1) Ensembl 9,709 nt
mRNA slc6a9-202 (1) Ensembl 1,935 nt
mRNA slc6a9-203 (1) Ensembl 2,372 nt
mRNA slc6a9-204 (1) Ensembl 254 nt
mRNA slc6a9-205 (1) Ensembl 1,962 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(slc6a9:EGFP)
  • slc6a9
  • Danio rerio
1Wang et al., 2020
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-261P7ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSLC6A91
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseSlc6a94
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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