Gene
nr1d1
- ID
- ZDB-GENE-050105-1
- Name
- nuclear receptor subfamily 1, group d, member 1
- Symbol
- nr1d1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within autophagy; circadian regulation of gene expression; and regulation of locomotor rhythm. Located in chromatin. Is expressed in nervous system. Human ortholog(s) of this gene implicated in brain small vessel disease. Orthologous to human NR1D1 (nuclear receptor subfamily 1 group D member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- ay391444 (13 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nr1d1 | Zebrafish Nomenclature Committee | |
| CRISPR2-nr1d1 | (2) | |
| CRISPR3-nr1d1 | (2) | |
| MO1-nr1d1 | N/A | Kakizawa et al., 2007 |
| MO2-nr1d1 | N/A | Kakizawa et al., 2007 |
| TALEN1-nr1d1 | (2) |
1 - 6 of 6
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR001728 | Thyroid hormone receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Thyroid hormone receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RAU6 | InterPro | 637 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(nr1d1-Mmu.Fos:EGFP) |
|
| 2 | Lickwar et al., 2017 | |
| Tg(nr1d1:Venus-NLS) |
|
| 1 | Wang et al., 2020 |
1 - 2 of 2
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-225F5 | ZFIN Curated Data | |
| Encodes | EST | ay391444 | Bertrand et al., 2007 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205729 (1) | 2957 nt | ||
| Genomic | GenBank:BX682558 (1) | 99226 nt | ||
| Polypeptide | UniProtKB:F1RAU6 (1) | 637 aa |
- Wang, Y., Sun, X., Xiong, B., Duan, M., Sun, Y. (2024) Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish. International Journal of Molecular Sciences. 25(17):
- Aranda-Martínez, P., Fernández-Martínez, J., Ramírez-Casas, Y., Rodríguez-Santana, C., Rusanova, I., Escames, G., Acuña-Castroviejo, D. (2023) Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment. Antioxidants (Basel, Switzerland). 12(4):
- Osorio-Méndez, D., Miller, A., Begeman, I.J., Kurth, A., Hagle, R., Rolph, D., Dickson, A.L., Chen, C.H., Halloran, M., Poss, K.D., Kang, J. (2022) Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins. Proceedings of the National Academy of Sciences of the United States of America. 119:e2200342119
- Shi, W.J., Long, X.B., Li, S.Y., Ma, D.D., Liu, F., Zhang, J.G., Lu, Z.J., Ying, G.G. (2022) Dydrogesterone and levonorgestrel at environmentally relevant concentrations have antagonist effects with rhythmic oscillation in brain and eyes of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 248:106177
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Bolton, C.M., Bekaert, M., Eilertsen, M., Helvik, J.V., Migaud, H. (2021) Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain. Frontiers in Physiology. 12:761109
- Klatt Shaw, D., Mokalled, M.H. (2021) Efficient CRISPR/Cas9 mutagenesis for neurobehavioral screening in adult zebrafish. G3 (Bethesda). 11(8):
- Klatt Shaw, D., Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Butka, E., Morris, S.A., Dietmann, S., Mokalled, M.H. (2021) Localized EMT reprograms glial progenitors to promote spinal cord repair. Developmental Cell. 56(5):613-626.e7
- Ren, J., Long, Y., Liu, R., Song, G., Li, Q., Cui, Z. (2021) Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. International Journal of Molecular Sciences. 22(6):
- Safarian, N., Houshangi-Tabrizi, S., Zoidl, C., Zoidl, G.R. (2021) Panx1b Modulates the Luminance Response and Direction of Locomotion in the Zebrafish. International Journal of Molecular Sciences. 22(21):
1 - 10 of 67
Show