Gene

cbl

ID
ZDB-GENE-041114-207
Name
Cbl proto-oncogene, E3 ubiquitin protein ligase
Symbol
cbl Nomenclature History
Previous Names
  • wu:fd16a12
  • zgc:92560 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in definitive hemopoiesis. Predicted to localize to membrane raft and plasma membrane. Used to study myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Peng et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cbl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
juvenile myelomonocytic leukemia Alliance ?Juvenile myelomonocytic leukemia 607785
Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia 613563
Associated With cbl Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017907 Zinc finger, RING-type, conserved site
Domain IPR001841 Zinc finger, RING-type
Domain IPR003153 Adaptor protein Cbl, N-terminal helical
Domain IPR014741 Adaptor protein Cbl, EF hand-like
Domain IPR014742 Adaptor protein Cbl, SH2-like domain
Domain IPR015940 Ubiquitin-associated domain
Domain IPR024159 Adaptor protein Cbl, PTB domain
Domain IPR039520 E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass
Family IPR024162 Adaptor protein Cbl
Homologous_superfamily IPR009060 UBA-like superfamily
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR036537 Adaptor protein Cbl, N-terminal domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Adaptor protein Cbl Adaptor protein Cbl, EF hand-like Adaptor protein Cbl, N-terminal domain superfamily Adaptor protein Cbl, N-terminal helical Adaptor protein Cbl, PTB domain Adaptor protein Cbl, SH2-like domain E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass EF-hand domain pair SH2 domain superfamily UBA-like superfamily Ubiquitin-associated domain Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, RING-type, conserved site
UniProtKB:F1QI90 913
UniProtKB:Q5U376 913
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations