Gene

pomcb

ID

ZDB-GENE-041014-294

Name

proopiomelanocortin b

Symbol

pomcb Nomenclature History

Previous Names

pomc-like (1)
si:ch211-203k16.2

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have neuropeptide hormone activity. Involved in regulation of hematopoietic stem cell differentiation. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in familial Mediterranean fever; obesity; and osteoarthritis. Is expressed in brain and preoptic area. Orthologous to human POMC (proopiomelanocortin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Shi et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pomcb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
obesity	Alliance	{Obesity, early-onset, susceptibility to}	601665
		Obesity, adrenal insufficiency, and red hair due to POMC deficiency	609734

Associated With pomcb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013531	Pro-opiomelanocortin/corticotropin, ACTH, central region
Domain	IPR013532	Opiodes neuropeptide
Family	IPR001941	Pro-opiomelanocortin
Family	IPR050878	Pro-opiomelanocortin-derived peptides