lin7c

ID

ZDB-GENE-041011-2

Name

lin-7 homolog C (C. elegans)

Symbol

lin7c Nomenclature History

Previous Names

fb75b09
wu:fb75b09
zgc:101881

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables L27 domain binding activity. Acts upstream of or within maintenance of epithelial cell apical/basal polarity. Predicted to be located in bicellular tight junction and plasma membrane. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and synapse. Is expressed in several structures, including eye; neural rod; neural tube; neuroepithelial cell; and optic vesicle. Orthologous to human LIN7C (lin-7 homolog C, crumbs cell polarity complex component).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Yang et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lin7c Human Ortholog

No data available

Associated With lin7c Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001478	PDZ domain
Domain	IPR004172	L27 domain
Domain	IPR014775	L27 domain, C-terminal
Family	IPR017365	Protein lin-7
Family	IPR051109	Membrane-associated multiprotein complex regulator
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036892	L27 domain superfamily