Gene
gpd1l
- ID
- ZDB-GENE-041010-220
- Name
- glycerol-3-phosphate dehydrogenase 1 like
- Symbol
- gpd1l Nomenclature History
- Previous Names
-
- wu:fi13g03
- wu:fi45b08
- zgc:92580
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable NAD binding activity; glycerol-3-phosphate dehydrogenase (NAD+) activity; and protein homodimerization activity. Predicted to act upstream of or within carbohydrate metabolic process and glycerol-3-phosphate catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1L (glycerol-3-phosphate dehydrogenase 1 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92580 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Brugada syndrome 2 | Alliance | Brugada syndrome 2 | 611777 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006109 | Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal |
| Domain | IPR011128 | Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal |
| Family | IPR006168 | Glycerol-3-phosphate dehydrogenase, NAD-dependent |
| Family | IPR017751 | Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic |
| Homologous_superfamily | IPR008927 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR013328 | 6-phosphogluconate dehydrogenase, domain 2 |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 6-phosphogluconate dehydrogenase, domain 2 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | Glycerol-3-phosphate dehydrogenase, NAD-dependent | Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal | Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic | Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5XIZ6 | InterPro | 351 | |||||||
| UniProtKB:A0AB32T819 | InterPro | 351 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-99N20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-219N14 | ZFIN Curated Data | |
| Contains | SNP | rs3728408 | ZFIN Curated Data | |
| Contains | SNP | rs3728409 | ZFIN Curated Data | |
| Contains | SNP | rs3728410 | ZFIN Curated Data | |
| Contains | SNP | rs3728411 | ZFIN Curated Data | |
| Contains | SNP | rs3728412 | ZFIN Curated Data | |
| Contains | SNP | rs3728413 | ZFIN Curated Data | |
| Contains | SNP | rs3728414 | ZFIN Curated Data | |
| Contains | SNP | rs3728415 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005934 (1) | 2721 nt | ||
| Genomic | GenBank:CR925805 (2) | 162560 nt | ||
| Polypeptide | UniProtKB:A0AB32T819 (1) | 351 aa |
- Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish. The Science of the total environment. 702:134969
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nojima, H., Rothhämel, S., Shimizu, T., Kim, C.H., Yonemura, S., Marlow, F.L., and Hibi, M. (2010) Syntabulin, a motor protein linker, controls dorsal determination. Development (Cambridge, England). 137(6):923-933
- Leung, Y.F., Ma, P., and Dowling, J.E. (2007) Gene expression profiling of zebrafish embryonic retinal pigment epithelium in vivo. Investigative ophthalmology & visual science. 48(2):881-890
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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