Gene
polr2a
- ID
- ZDB-GENE-041008-78
- Name
- RNA polymerase II subunit A
- Symbol
- polr2a Nomenclature History
- Previous Names
-
- im:7136071 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable nucleic acid binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in mRNA transcription by RNA polymerase II. Predicted to be located in chromosome; cytoplasm; and nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Is expressed in blastomere. Orthologous to human POLR2A (RNA polymerase II subunit A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136071 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities | 618603 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000722 | RNA polymerase, alpha subunit |
| Domain | IPR006592 | RNA polymerase, N-terminal |
| Domain | IPR007066 | RNA polymerase Rpb1, domain 3 |
| Domain | IPR007073 | RNA polymerase Rpb1, domain 7 |
| Domain | IPR007075 | RNA polymerase Rpb1, domain 6 |
| Domain | IPR007080 | RNA polymerase Rpb1, domain 1 |
| Domain | IPR007081 | RNA polymerase Rpb1, domain 5 |
| Domain | IPR007083 | RNA polymerase Rpb1, domain 4 |
| Family | IPR045867 | DNA-directed RNA polymerase, subunit beta-prime |
| Homologous_superfamily | IPR038120 | RNA polymerase Rpb1, funnel domain superfamily |
| Homologous_superfamily | IPR038593 | RNA polymerase Rpb1, domain 7 superfamily |
| Homologous_superfamily | IPR042102 | RNA polymerase Rpb1, domain 3 superfamily |
| Homologous_superfamily | IPR044893 | RNA polymerase Rpb1, clamp domain superfamily |
| Repeat | IPR000684 | RNA polymerase II, heptapeptide repeat, eukaryotic |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA-directed RNA polymerase, subunit beta-prime | RNA polymerase, alpha subunit | RNA polymerase II, heptapeptide repeat, eukaryotic | RNA polymerase, N-terminal | RNA polymerase Rpb1, clamp domain superfamily | RNA polymerase Rpb1, domain 1 | RNA polymerase Rpb1, domain 3 | RNA polymerase Rpb1, domain 3 superfamily | RNA polymerase Rpb1, domain 4 | RNA polymerase Rpb1, domain 5 | RNA polymerase Rpb1, domain 6 | RNA polymerase Rpb1, domain 7 | RNA polymerase Rpb1, domain 7 superfamily | RNA polymerase Rpb1, funnel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IMS9 | InterPro | 1965 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
polr2a-201
(1)
|
Ensembl | 8,182 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-polr2a | monoclonal | IgG2a | Mouse |
|
Santa Cruz Biotechnology, Inc.
Covance |
9 | |
| Ab2-polr2a | monoclonal | IgG1 | Mouse |
|
Santa Cruz Biotechnology, Inc.
Covance |
4 |
Plasmids
No data available