Gene
aldh8a1
- ID
- ZDB-GENE-040912-3
- Name
- aldehyde dehydrogenase 8 family, member A1
- Symbol
- aldh8a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable retinal dehydrogenase activity. Acts upstream of or within liver development. Predicted to be located in cytoplasm. Is expressed in intestinal bulb; intestinal bulb epithelium; intestine; and liver. Orthologous to human ALDH8A1 (aldehyde dehydrogenase 8 family member A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92068 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Garnaas et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-aldh8a1 | N/A | Ma et al., 2010 |
| MO2-aldh8a1 | N/A | Garnaas et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| Conserved_site | IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
| Homologous_superfamily | IPR016162 | Aldehyde dehydrogenase, N-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase, cysteine active site | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase, glutamic acid active site | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A9YD19 | InterPro | 487 | ||||||
| UniProtKB:Q66I21 | InterPro | 487 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh8a1-201
(1)
|
Ensembl | 1,690 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-161P7 | ZFIN Curated Data | |
| Encodes | EST | fi34g05 | ||
| Encodes | cDNA | MGC:92068 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173794 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004540 (1) | 1673 nt | ||
| Genomic | GenBank:BX927365 (1) | 229608 nt | ||
| Polypeptide | UniProtKB:A9YD19 (1) | 487 aa |
- Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L.C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A.H.Y., Schofield, C.J., von Kriegsheim, A., Marsh, J.A., Pavet, V., Sansom, O.J., Illingworth, R.S., Patton, E.E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports. 43:114406114406
- Brunsdon, H., Brombin, A., Peterson, S., Postlethwait, J.H., Patton, E.E. (2022) Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Development (Cambridge, England). 149(10):
- Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723
- Jiménez-Amilburu, V., Jong-Raadsen, S., Bakkers, J., Spaink, H.P., Marín-Juez, R. (2015) GLUT12 deficiency during early development results in heart failure and a diabetic phenotype. The Journal of endocrinology. 224(1):1-15
- Garnaas, M.K., Cutting, C.C., Meyers, A., Kelsey, P.B., Harris, J.M., North, T.E., and Goessling, W. (2012) Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Developmental Biology. 372(2):178-189
- Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K.L., Temperley, N.D., Johnson, S.L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E.M., Melton, D.W., Smith, T.K., Tyers, M., Westwood, N.J., and Patton, E.E. (2012) ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species. Chemistry & Biology. 19(7):883-892
- Castillo, H.A., Cravo, R.M., Azambuja, A.P., Simões-Costa, M.S., Sura-Trueba, S., Gonzalez, J., Slonimsky, E., Almeida, K., Abreu, J.G., de Almeida, M.A., Sobreira, T.P., de Oliveira, S.H., de Oliveira, P.S., Signore, I.A., Colombo, A., Concha, M.L., Spengler, T.S., Bronner-Fraser, M., Nobrega, M., Rosenthal, N., and Xavier-Neto, J. (2010) Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer. Development (Cambridge, England). 137(3):507-518
- Gibert, Y., Bernard, L., Debiais-Thibaud, M., Bourrat, F., Joly, J.S., Pottin, K., Meyer, A., Retaux, S., Stock, D.W., Jackman, W.R., Seritrakul, P., Begemann, G., and Laudet, V. (2010) Formation of oral and pharyngeal dentition in teleosts depends on differential recruitment of retinoic acid signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(9):3298-3309
- Ma, A.C., Chung, M.I., Liang, R., and Leung, A.Y. (2010) A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Leukemia. 24(12):2090-2099
- Hoffmann, J.L., Thomason, R.G., Lee, D.M., Brill, J.L., Price, B.B., Carr, G.J., and Versteeg, D.J. (2008) Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone. Aquatic toxicology (Amsterdam, Netherlands). 87(2):69-80
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