Gene
bmpr1ab
- ID
- ZDB-GENE-040912-150
- Name
- bone morphogenetic protein receptor, type IAb
- Symbol
- bmpr1ab Nomenclature History
- Previous Names
-
- alk3b (1)
- wu:fe05b06
- wu:fe06e10
- zgc:92227
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have SMAD binding activity and transforming growth factor beta receptor activity, type I. Involved in BMP signaling pathway; circulatory system development; and regionalization. Predicted to localize to plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Is expressed in several structures, including blastoderm; blastodisc; cardinal system; head; and ovarian follicle. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Little et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary mixed polyposis syndrome 2 | Alliance | Polyposis syndrome, hereditary mixed, 2 | 610069 |
| juvenile polyposis syndrome | Alliance | Polyposis, juvenile intestinal | 174900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR003605 | GS domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Activin types I and II receptor domain | GS domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66HY1
|
534 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bmpr1ab-201
(1)
|
Ensembl | 3,258 nt |
Interactions and Pathways
No data available
Plasmids
No data available