Gene

agrp

ID
ZDB-GENE-040817-1
Name
agouti related neuropeptide
Symbol
agrp Nomenclature History
Previous Names
  • agrp1 (1)
  • si:dkey-193l8.2
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables melanocortin receptor binding activity and neuropeptide hormone activity. Acts upstream of or within with a positive effect on feeding behavior. Acts upstream of or within several processes, including neuropeptide signaling pathway; positive regulation of feeding behavior; and regulation of growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; female organism; and male organism. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human AGRP (agouti related neuropeptide).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
23 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With agrp Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
obesity Alliance {Leanness, inherited} 601665
obesity Alliance {Obesity, late-onset} 601665
Associated With agrp Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR027300 Agouti domain
Family IPR007733 Agouti
Homologous_superfamily IPR036836 Agouti domain superfamily
Domain Details Per Protein
Protein Length Agouti Agouti domain Agouti domain superfamily
UniProtKB:A0A2R8PWU9 129
UniProtKB:E9QBS3 126
UniProtKB:A0A2R8QM92 127
UniProtKB:A0A1D5NSV7 36
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-agrp polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations