Gene

agrp

ID

ZDB-GENE-040817-1

Name

agouti related neuropeptide

Symbol

agrp Nomenclature History

Previous Names

agrp1 (1)
si:dkey-193l8.2

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Enables melanocortin receptor binding activity and neuropeptide hormone activity. Acts upstream of or within with a positive effect on feeding behavior. Acts upstream of or within several processes, including neuropeptide signaling pathway; positive regulation of feeding behavior; and regulation of growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; female organism; and male organism. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human AGRP (agouti related neuropeptide).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 17 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With agrp Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
obesity	Alliance	{Leanness, inherited}	601665
obesity	Alliance	{Obesity, late-onset}	601665

Associated With agrp Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR027300	Agouti domain
Family	IPR007733	Agouti
Homologous_superfamily	IPR036836	Agouti domain superfamily

Domain Details Per Protein

Protein	Length	Agouti	Agouti domain	Agouti domain superfamily
UniProtKB:A0A8M1P467 InterPro	127

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	agrp-201 (1) Ensembl	Ensembl	555 nt	Select Tool ZFIN BLAST
mRNA	agrp-202 (1) Ensembl	Ensembl	677 nt	Select Tool ZFIN BLAST
mRNA	agrp-203 (1) Ensembl	Ensembl	203 nt	Select Tool ZFIN BLAST
mRNA	agrp-204 (1) Ensembl	Ensembl	1,676 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-agrp	polyclonal	agrp		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations