Gene
mob4
- ID
- ZDB-GENE-040801-174
- Name
- MOB family member 4, phocein
- Symbol
- mob4 Nomenclature History
- Previous Names
-
- mobkl3
- zgc:92671
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable kinase activity. Predicted to act upstream of or within phosphorylation. Is active in Z disc. Is expressed in several structures, including cardiovascular system; neuroectoderm; pronephros; skeletal muscle cell; and somite. Orthologous to human MOB4 (MOB family member 4, phocein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898838 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026914Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| pc43 | Allele with one point mutation | Exon 2 | Premature Stop | ENU | |
| pc44 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
1 - 3 of 3
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mob4 | Berger et al., 2022 | |
| CRISPR2-mob4 | Florindo et al., 2023 | |
| MO1-mob4 | N/A | (2) |
| MO2-mob4 | N/A | Berger et al., 2022 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | MOB kinase activator family | MOB kinase activator superfamily |
|---|---|---|---|---|
| UniProtKB:Q6DH28 | InterPro | 225 |
1 - 1 of 1
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mob4 | IgG | Rabbit |
|
Sigma-Aldrich
|
2 |
1 - 1 of 1
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.5unc45b:mob4,cryaa:GFP) |
|
| 1 | Berger et al., 2022 | |
| Tg(-0.5unc45b:mob4-GFP,cryaa:GFP) |
|
| 1 | Berger et al., 2022 |
1 - 2 of 2
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-117M22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-83M22 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6898838 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92671 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174743 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003439 (1) | 1113 nt | ||
| Genomic | GenBank:BX530407 (2) | 292409 nt | ||
| Polypeptide | UniProtKB:Q6DH28 (1) | 225 aa |
- Florindo, C., Mimoso, J.M., Palma, S.L., Gonçalves, C., Silvestre, D., Campinho, M., Tavares, Á.A. (2023) Mob4 is required for neurodevelopment in zebrafish. microPublication. Biology. 2023:
- Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51
- Rao, A., Lyu, B., Jahan, I., Lubertozzi, A., Zhou, G., Tedeschi, F., Jankowsky, E., Kang, J., Carstens, B., Poss, K.D., Baskin, K., Goldman, J.A. (2023) The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration. Development (Cambridge, England). 150(20):
- Stergas, H.R., Dillon-Martin, M., Dumas, C.M., Hansen, N.A., Carasi-Schwartz, F.J., D'Amico, A.R., Finnegan, K.M., Juch, U., Kane, K.R., Kaplan, I.E., Masengarb, M.L., Melero, M.E., Meyer, L.E., Sacher, C.R., Scriven, E.A., Ebert, A.M., Ballif, B.A. (2023) CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns. FEBS letters. 598(3):302-320
- Berger, J., Berger, S., Currie, P.D. (2022) Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth. PLoS Genetics. 18:e1010287
- Hason, M., Mikulasova, T., Machonova, O., Pombinho, A.R., van Ham, T.J., Irion, U., Nüsslein-Volhard, C., Bartunek, P., Svoboda, O. (2022) M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands. Blood advances. 6(5):1474-1488
- Jim, K.K., Aprianto, R., Koning, R., Domenech, A., Kurushima, J., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Bitter, W., Veening, J.W. (2022) Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole-animal dual RNA-seq. Cell Reports. 41:111851111851
- Rice, K.L., Webb, S.E., Miller, A.L. (2022) Localized TPC1-mediated Ca2+ release from endolysosomes contributes to myoseptal junction development in zebrafish. Journal of Cell Science. 135(9):
- Matsumoto, H., Scicluna, B.P., Jim, K.K., Falahi, F., Qin, W., Gürkan, B., Malmström, E., Meijer, M.T., Butler, J.M., Khan, H.N., Takagi, T., Ishii, S., Schultz, M.J., van de Beek, D., de Vos, A.F., van 't Veer, C., van der Poll, T. (2021) HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis. Frontiers in immunology. 12:744358
- Quan, F.B., Gaillard, A.L., Alejevski, F., Pézeron, G., Tostivint, H. (2021) Urotensin II-related peptide (Urp) is expressed in motoneurons in zebrafish, but is dispensable for locomotion in larva. Peptides. 146:170675
1 - 10 of 24
Show