Gene
atg5
- ID
- ZDB-GENE-040801-149
- Name
- ATG5 autophagy related 5 homolog (S. cerevisiae)
- Symbol
- atg5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to contribute to Atg8-family ligase activity. Acts upstream of or within several processes, including autophagosome assembly; heart development; and regulation of skeletal muscle tissue regeneration. Predicted to be located in cytoplasm and membrane. Predicted to be part of Atg12-Atg5-Atg16 complex. Predicted to be active in autophagosome; phagophore; and phagophore assembly site membrane. Is expressed in several structures, including heart; liver; male organism; nervous system; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145909 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-atg5 | Morishita et al., 2019 | |
| CRISPR2-atg5 | Prajsnar et al., 2020 | |
| CRISPR3-atg5 | Chen et al., 2023 | |
| MO1-atg5 | N/A | (9) |
| MO2-atg5 | N/A | Hu et al., 2011 |
| MO3-atg5 | N/A | (2) |
| MO4-atg5 | N/A | (6) |
| MO5-atg5 | N/A | Lee et al., 2014 |
| MO6-atg5 | N/A | Davuluri et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 25 | Alliance | ?Spinocerebellar ataxia, autosomal recessive 25 | 617584 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR048318 | Autophagy protein ATG5, UblB domain |
| Domain | IPR048939 | Autophagy protein ATG5, UblA domain |
| Domain | IPR048940 | Autophagy protein ATG5, alpha-helical bundle region |
| Family | IPR007239 | Autophagy-related protein 5 |
| Homologous_superfamily | IPR042526 | Autophagy protein Atg5, helix rich domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Autophagy protein ATG5, alpha-helical bundle region | Autophagy protein Atg5, helix rich domain | Autophagy protein ATG5, UblA domain | Autophagy protein Atg5, UblA domain superfamily | Autophagy protein ATG5, UblB domain | Autophagy-related protein 5 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RDC0 | InterPro | 275 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(mitfa:dnatg5_K130R) |
|
| 1 | Lee et al., 2016 | |
| Tg(UAS:atg5,myl7:EGFP) |
|
| 1 | Zebrafish Nomenclature Committee |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-11F5 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7145909 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100934 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001009914 (1) | 2279 nt | ||
| Genomic | GenBank:AL928573 (2) | 244471 nt | ||
| Polypeptide | UniProtKB:F1RDC0 (1) | 275 aa |
- Chen, X., Li, Y., Xu, J., Cui, Y., Wu, Q., Yin, H., Li, Y., Gao, C., Jiang, L., Wang, H., Wen, Z., Yao, Z., Wu, Z. (2024) Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation. eLIFE. 12:
- Giong, H.K., Hyeon, S.J., Lee, J.G., Cho, H.J., Park, U., Stein, T.D., Lee, J., Yu, K., Ryu, H., Lee, J.S. (2024) Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathologica. 148:4646
- Marchese, M., Bernardi, S., Ogi, A., Licitra, R., Silvi, G., Mero, S., Galatolo, D., Gammaldi, N., Doccini, S., Ratto, G.M., Rapposelli, S., Neuhauss, S.C.F., Zang, J., Rocchiccioli, S., Michelucci, E., Ceccherini, E., Santorelli, F.M. (2024) Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model. Neurobiology of disease. 197:106536
- Wang, Y., Sun, X., Xiong, B., Duan, M., Sun, Y. (2024) Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish. International Journal of Molecular Sciences. 25(17):
- Chen, X.K., Yi, Z.N., Lau, J.J., Ma, A.C. (2023) Distinct roles of core autophagy-related genes in zebrafish definitive hematopoiesis. Autophagy. 20(4):830-846
- Wang, Y., Bo, J., Zhao, Z., Han, Y., Zhang, Q., Liu, L. (2023) Depletion of Igfbp7 alleviates zebrafish NAFLD progression through inhibiting hepatic ferroptosis. Life sciences. 332:122086
- Wasilewska, I., Majewski, Ł., Adamek-Urbańska, D., Mondal, S.S., Baranykova, S., Gupta, R.K., Bielecki, D., Winata, C.L., Kuznicki, J. (2023) Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia. Zebrafish. 20:146159146-159
- Xu, F.H., Qiu, Y.Z., Zhang, Y., Yang, F.H., Ji, M.M., Liu, K.C., Jin, M., Zhang, S.S., Li, B. (2023) The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish. Food & function. 14(13):6157-6171
- Della Vecchia, S., Ogi, A., Licitra, R., Abramo, F., Nardi, G., Mero, S., Landi, S., Battini, R., Sicca, F., Ratto, G.M., Santorelli, F.M., Marchese, M. (2022) Trehalose Treatment in Zebrafish Model of Lafora Disease. International Journal of Molecular Sciences. 23(12)
- Kong, S., Zhou, D., Fan, Q., Zhao, T., Ren, C., Nie, H. (2022) Salviae miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection Protects against Myocardial Ischemia-Reperfusion Injury and Heart Failure. Computational and Mathematical Methods in Medicine. 2022:7809485
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