Gene

atg5

ID
ZDB-GENE-040801-149
Name
ATG5 autophagy related 5 homolog (S. cerevisiae)
Symbol
atg5 Nomenclature History
Previous Names
  • apg5l (1)
  • zgc:100934 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Involved in several processes, including autophagosome assembly; heart development; and regulation of skeletal muscle tissue regeneration. Predicted to localize to Atg12-Atg5-Atg16 complex and phagophore assembly site membrane. Is expressed in several structures, including central nervous system; head; liver; muscle; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atg5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 25 Alliance ?Spinocerebellar ataxia, autosomal recessive 25 617584
Associated With atg5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR007239 Autophagy-related protein 5
Homologous_superfamily IPR042526 Autophagy protein Atg5, helix rich domain
Homologous_superfamily IPR042527 Autophagy protein Atg5, UblA domain
Domain Details Per Protein
Protein Length Autophagy protein Atg5, helix rich domain Autophagy protein Atg5, UblA domain Autophagy-related protein 5
UniProtKB:F1RDC0 275
UniProtKB:Q6TH46 275
UniProtKB:F5ATB3 275
UniProtKB:Q6DEM4 273
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab4-atg5 polyclonal Rabbit
  • WB
Novus Biologicals, LLC
6
Ab1-atg5 polyclonal Rabbit
  • IHC
  • WB
Abcam plc
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations