Gene
atg5
- ID
- ZDB-GENE-040801-149
- Name
- ATG5 autophagy related 5 homolog (S. cerevisiae)
- Symbol
- atg5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to contribute to Atg8 ligase activity. Acts upstream of or within several processes, including autophagosome assembly; heart development; and regulation of skeletal muscle tissue regeneration. Predicted to be located in cytoplasm and membrane. Predicted to be part of Atg12-Atg5-Atg16 complex. Predicted to be active in phagophore assembly site membrane. Is expressed in several structures, including central nervous system; head; liver; male organism; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145909 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 25 | Alliance | ?Spinocerebellar ataxia, autosomal recessive 25 | 617584 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Autophagy protein Atg5, helix rich domain | Autophagy protein Atg5, UblA domain | Autophagy-related protein 5 |
|---|---|---|---|---|
|
UniProtKB:Q6TH46
|
275 | |||
|
UniProtKB:Q6DEM4
|
273 | |||
|
UniProtKB:F5ATB3
|
275 | |||
|
UniProtKB:F1RDC0
|
275 |
Interactions and Pathways
No data available
Plasmids
No data available