Gene
rorcb
- ID
- ZDB-GENE-040724-215
- Name
- RAR-related orphan receptor C b
- Symbol
- rorcb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in intestinal bulb; nervous system; and presumptive diencephalon. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017628 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa322 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 42 | Alliance | Immunodeficiency 42 | 616622 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR044101 | Retinoid-related orphan receptors, DNA-binding domain |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003079 | Nuclear receptor ROR |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Nuclear receptor ROR | Retinoid-related orphan receptors, DNA-binding domain | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8JJ08 | InterPro | 480 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-168N16 | ||
| Contained in | BAC | DKEY-158A20 | ZFIN Curated Data | |
| Encodes | EST | dq017628 | Bertrand et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001277094 (1) | 2127 nt | ||
| Genomic | GenBank:CR926137 (1) | 184144 nt | ||
| Polypeptide | UniProtKB:B8JJ08 (1) | 480 aa |
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Bolton, C.M., Bekaert, M., Eilertsen, M., Helvik, J.V., Migaud, H. (2021) Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain. Frontiers in Physiology. 12:761109
- Zheng, X., Zhang, K., Zhao, Y., Fent, K. (2021) Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans. Environment International. 149:106159
- Zhao, Y., Zhang, K., Fent, K. (2018) Regulation of zebrafish (Danio rerio) locomotor behavior and circadian rhythm network by environmental steroid hormones. Environmental pollution (Barking, Essex : 1987). 232:422-429
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Chi, H., Bøgwald, J., Dalmo, R.A., Zhang, W., Hu, Y.H. (2016) Th17 master transcription factors RORα and RORγ regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevis. Developmental and comparative immunology. 55:169-78
- Zhao, Y., Fent, K. (2016) Progestins alter photo-transduction cascade and circadian rhythm network in eyes of zebrafish (Danio rerio). Scientific Reports. 6:21559
- Zhao, Y., Zhang, K., Fent, K. (2016) Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations. Environmental science & technology. 50(18):10245-54
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhao, Y., Castiglioni, S., Fent, K. (2015) Environmental progestins progesterone and drospirenone alter the circadian rhythm network in zebrafish (Danio rerio). Environmental science & technology. 49(16):10155-64
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