Gene
serpina1l
- ID
- ZDB-GENE-040721-3
- Name
- serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
- Symbol
- serpina1l Nomenclature History
- Previous Names
-
- cb301 (1)
- fb70a01
- sb:cb301
- wu:fb66d09
- wu:fb70a01
- zgc:136659
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to several human genes including SERPINA1 (serpin family A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb301 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023795 | Serpin, conserved site |
| Domain | IPR023796 | Serpin domain |
| Family | IPR000215 | Serpin family |
| Homologous_superfamily | IPR036186 | Serpin superfamily |
| Homologous_superfamily | IPR042178 | Serpin superfamily, domain 1 |
| Homologous_superfamily | IPR042185 | Serpin superfamily, domain 2 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7V0N1 | InterPro | 433 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpina1l-201
(1)
|
Ensembl | 1,657 nt | ||
| mRNA |
serpina1l-202
(1)
|
Ensembl | 1,392 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-121D13 | ||
| Encodes | EST | cb301 | Thisse et al., 2001 | |
| Encodes | EST | fb66d09 | ZFIN Curated Data | |
| Encodes | EST | fb70a01 | ||
| Encodes | cDNA | MGC:136659 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013259 (1) | 1653 nt | ||
| Genomic | GenBank:AL845550 (2) | 163676 nt | ||
| Polypeptide | UniProtKB:A0A8N7V0N1 (1) | 433 aa |
No data available
- Jin, Q., Hu, Y., Gao, Y., Zheng, J., Chen, J., Gao, C., Peng, J. (2023) Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish. Biochemical and Biophysical Research Communications. 686:149182149182
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Jin, Q., Gao, Y., Shuai, S., Chen, Y., Wang, K., Chen, J., Peng, J., Gao, C. (2022) Cdx1b protects intestinal cell fate by repressing signaling networks for liver specification. Journal of genetics and genomics = Yi chuan xue bao. 49(12):1101-1113
- Norcross, R.G., Abdelmoti, L., Rouchka, E.C., Andreeva, K., Tussey, O., Landestoy, D., Galperin, E. (2022) Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix. Developmental Biology. 492:156-171
- So, J., Kim, M., Lee, S.H., Ko, S., Lee, D.A., Park, H., Azuma, M., Parsons, M.J., Prober, D., Shin, D. (2020) Attenuating the EGFR-ERK-SOX9 axis promotes liver progenitor cell-mediated liver regeneration in zebrafish. Hepatology (Baltimore, Md.). 73(4):1494-1508
- Schmid, S., Fent, K. (2019) 17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish. Environmental pollution (Barking, Essex : 1987). 259:113808
- van der Helm, D., Groenewoud, A., de Jonge-Muller, E.S.M., Barnhoorn, M.C., Schoonderwoerd, M.J.A., Coenraad, M.J., Hawinkels, L.J.A.C., Snaar-Jagalska, B.E., van Hoek, B., Verspaget, H.W. (2018) Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model. Scientific Reports. 8:16005
- Zhang, Q., Ji, C., Ren, J., Zhang, Q., Dong, X., Zu, Y., Jia, L., Li, W. (2018) Differential transcriptome analysis of zebrafish (Danio rerio) larvae challenged by Vibrio parahaemolyticus. Journal of fish diseases. 41(7):1049-1062
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Li, C., Tan, X.F., Lim, T.K., Lin, Q., Gong, Z. (2016) Comprehensive and quantitative proteomic analyses of zebrafish plasma reveals conserved protein profiles between genders and between zebrafish and human. Scientific Reports. 6:24329
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