Gene
rgs2
- ID
- ZDB-GENE-040718-410
- Name
- regulator of G protein signaling 2
- Symbol
- rgs2 Nomenclature History
- Previous Names
-
- fa96c08
- wu:fa96c08
- wu:fj08f11
- zgc:91965
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of neural crest formation and neural crest cell development. Predicted to be located in cytoplasm; membrane; and nucleus. Is expressed in cephalic mesoderm; digestive system; nervous system; and neural crest cell. Orthologous to human RGS2 (regulator of G protein signaling 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91965 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Lin et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rgs2 | N/A | Lin et al., 2017 |
| MO2-rgs2 | N/A | Lin et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | RGS domain | RGS domain superfamily | RGS, subdomain 2 |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1N0Y4 | InterPro | 199 | |||
| UniProtKB:Q6DG95 | InterPro | 172 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-117L17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-53B10 | ZFIN Curated Data | |
| Contains | SNP | rs3729194 | ZFIN Curated Data | |
| Encodes | EST | fa96c08 | ||
| Encodes | EST | fj08f11 | ||
| Encodes | cDNA | MGC:91965 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113910 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002662 (1) | 1080 nt | ||
| Genomic | GenBank:BX936311 (1) | 192750 nt | ||
| Polypeptide | UniProtKB:A0A8M1N0Y4 (1) | 199 aa |
- Yehuda, H., Madrer, N., Goldberg, D., Soreq, H., Meerson, A. (2023) Inversely Regulated Inflammation-Related Processes Mediate Anxiety-Obesity Links in Zebrafish Larvae and Adults. Cells. 12(13):
- Campbell, C.A., Fursova, O., Cheng, X., Snella, E., McCune, A., Li, L., Solchenberger, B., Schmid, B., Sahoo, D., Morton, M., Traver, D., Espín-Palazón, R. (2021) A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation. Blood advances. 5:796-811
- Han, S., Zhang, D., Dong, Q., Wang, X., Wang, L. (2021) Overexpression of neuroserpin in larval and adult zebrafish shows different behavioral phenotypes. Neuroscience letters. 762:136175
- Han, S., Fei, F., Sun, S., Zhang, D., Dong, Q., Wang, X., Wang, L. (2020) Increased anxiety was found in serpini1 knockout zebrafish larval. Biochemical and Biophysical Research Communications. 534:1013-1019
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Huo, X., Li, H., Li, Z., Yan, C., Agrawal, I., Mathavan, S., Liu, J., Gong, Z. (2019) Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Scientific Reports. 9:1509
- Qiu, W., Liu, S., Yang, F., Dong, P., Yang, M., Wong, M., Zheng, C. (2019) Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Ecotoxicology and environmental safety. 174:181-188
- Yang, L., Jiang, H., Chen, J., Lei, Y., Sun, N., Lv, W., Near, T.J., He, S. (2019) Comparative Genomics Reveals Accelerated Evolution of Fright Reaction Genes in Ostariophysan Fishes. Frontiers in genetics. 10:1283
- Lin, S.J., Chiang, M.C., Shih, H.Y., Hsu, L.S., Yeh, T.H., Huang, Y.C., Lin, C.Y., Cheng, Y.C. (2017) Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade. Biochimica et biophysica acta. 1864(3):463-474
- Liu, D., Brewer, M.S., Chen, S., Hong, W., Zhu, Y. (2017) Transcriptomic Signatures for Ovulation in Vertebrates. General and comparative endocrinology. 247:74-86
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