ZFIN is now using GRCz12tu for Genomic Data
Gene
sirt5
- ID
- ZDB-GENE-040718-349
- Name
- sirtuin 5
- Symbol
- sirt5 Nomenclature History
- Previous Names
-
- zgc:92288
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables acyl binding activity and heterocyclic compound binding activity. Predicted to be involved in protein deacylation and regulation of ketone biosynthetic process. Predicted to be active in cytosol; mitochondrial matrix; and nucleus. Is expressed in liver and retina. Orthologous to human SIRT5 (sirtuin 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92288 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gut et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR026590 | Sirtuin family, catalytic core domain |
| Family | IPR003000 | Sirtuin family |
| Family | IPR027546 | Sirtuin, class III |
| Family | IPR050134 | NAD-dependent sirtuin protein deacylases |
| Homologous_superfamily | IPR026591 | Sirtuin, catalytic core small domain superfamily |
| Homologous_superfamily | IPR029035 | DHS-like NAD/FAD-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | DHS-like NAD/FAD-binding domain superfamily | NAD-dependent sirtuin protein deacylases | Sirtuin, catalytic core small domain superfamily | Sirtuin, class III | Sirtuin family | Sirtuin family, catalytic core domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BHG7 | InterPro | 277 | ||||||
| UniProtKB:Q6DHI5 | InterPro PDB | 305 |
Interactions and Pathways
No data available
Plasmids
No data available