Gene
s100b
- ID
- ZDB-GENE-040718-290
- Name
- S100 calcium binding protein, beta (neural)
- Symbol
- s100b Nomenclature History
- Previous Names
-
- si:dkey-110p14.2
- wu:fq18b10
- zgc:92776
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including RAGE receptor binding activity; S100 protein binding activity; and calcium-dependent protein binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction and positive regulation of cell population proliferation. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular region. Predicted to be active in cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including digestive system; heart; integument; nervous system; and renal system. Human ortholog(s) of this gene implicated in Alzheimer's disease; aspergillosis; and schizophrenia. Orthologous to human S100B (S100 calcium binding protein B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-hand domain | EF-hand domain pair | Protein S100-B | S100/CaBP-9k-type, calcium binding, subdomain | S100/Calcium binding protein 7/8-like, conserved site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DGT8 | InterPro | 95 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-s100 | polyclonal | Rabbit |
|
Dako North America, Inc.
|
80 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-110P14 | ZFIN Curated Data | |
| Encodes | EST | fq16d12 | Rauch et al., 2003 | |
| Encodes | EST | fq18b10 | ||
| Encodes | cDNA | MGC:92776 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002552 (1) | 1225 nt | ||
| Genomic | GenBank:BX649510 (2) | 150194 nt | ||
| Polypeptide | UniProtKB:Q6DGT8 (1) | 95 aa |
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Kuil, L.E., Kakiailatu, N.J.M., Windster, J.D., Bindels, E., Zink, J.T.M., van der Zee, G., Hofstra, R.M.W., Shepherd, I.T., Melotte, V., Alves, M.M. (2023) Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level. iScience. 26:107070107070
- An, G., Park, H., Lim, W., Song, G. (2021) Fluroxypyr-1-methylheptyl ester interferes with the normal embryogenesis of zebrafish by inducing apoptosis, inflammation, and neurovascular toxicity. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 247:109069
- D'Gama, P.P., Qiu, T., Cosacak, M.I., Rayamajhi, D., Konac, A., Hansen, J.N., Ringers, C., Acuña-Hinrichsen, F., Hui, S.P., Olstad, E.W., Chong, Y.L., Lim, C.K.A., Gupta, A., Ng, C.P., Nilges, B.S., Kashikar, N.D., Wachten, D., Liebl, D., Kikuchi, K., Kizil, C., Yaksi, E., Roy, S., Jurisch-Yaksi, N. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell Reports. 37:109775
- Umans, R.A., Pollock, C., Mills, W.A., Clark, K.C., Pan, Y.A., Sontheimer, H. (2021) Using Zebrafish to Elucidate Glial-Vascular Interactions During CNS Development. Frontiers in cell and developmental biology. 9:654338
- Erbaba, B., Burhan, Ö.P., Şerifoğlu, N., Muratoğlu, B., Kahveci, F., Adams, M.M., Arslan-Ergül, A. (2020) Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging. Neurobiology of aging. 94:164-175
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Sarti, S., De Paolo, R., Ippolito, C., Pucci, A., Pitto, L., Poliseno, L. (2020) Inducible modulation of miR-204 levels in a zebrafish melanoma model. Biology Open. 9(11):
- Cosacak, M.I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., Kizil, C. (2019) Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity. Cell Reports. 27:1307-1318.e3
- Zhang, C., Zhang, Q., Wang, J., Tian, J., Song, Y., Xie, H., Chang, M., Nie, P., Gao, Q., Zou, J. (2019) Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Fish & shellfish immunology. 94:685-696
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