Gene

pcca

ID
ZDB-GENE-040718-246
Name
propionyl-CoA carboxylase subunit alpha
Symbol
pcca Nomenclature History
Previous Names
  • fb92g02
  • wu:fb92g02
  • zgc:100925
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Is predicted to enable propionyl-CoA carboxylase activity. Acts upstream of or within lipid catabolic process. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; optic tectum; and segmental plate. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCA (propionyl-CoA carboxylase subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pcca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
propionic acidemia Alliance Propionicacidemia 606054
Associated With pcca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR001882 Biotin-binding site
Domain IPR000089 Biotin/lipoyl attachment
Domain IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
Domain IPR005481 Biotin carboxylase-like, N-terminal domain
Domain IPR005482 Biotin carboxylase, C-terminal
Domain IPR011761 ATP-grasp fold
Domain IPR011764 Biotin carboxylation domain
Domain IPR041265 Propionyl-coenzyme A carboxylase, BT domain
Homologous_superfamily IPR011053 Single hybrid motif
Homologous_superfamily IPR011054 Rudiment single hybrid motif
Homologous_superfamily IPR013815 ATP-grasp fold, subdomain 1
Homologous_superfamily IPR016185 Pre-ATP-grasp domain superfamily
Domain Details Per Protein
Protein Length ATP-grasp fold ATP-grasp fold, subdomain 1 Biotin-binding site Biotin carboxylase, C-terminal Biotin carboxylase-like, N-terminal domain Biotin carboxylation domain Biotin/lipoyl attachment Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain Pre-ATP-grasp domain superfamily Propionyl-coenzyme A carboxylase, BT domain Rudiment single hybrid motif Single hybrid motif
UniProtKB:B0S5E3 152
UniProtKB:F1QPL7 721
UniProtKB:A0A2R8PV58 693
UniProtKB:B0S5E2 159
UniProtKB:Q6DGE2 709
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations