Gene
pcca
- ID
- ZDB-GENE-040718-246
- Name
- propionyl-CoA carboxylase subunit alpha
- Symbol
- pcca Nomenclature History
- Previous Names
-
- fb92g02
- wu:fb92g02
- zgc:100925
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable propionyl-CoA carboxylase activity. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; optic tectum; and segmental plate. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCA (propionyl-CoA carboxylase subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6897355 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| propionic acidemia | Alliance | Propionicacidemia | 606054 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001882 | Biotin-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
| Domain | IPR005481 | Biotin carboxylase-like, N-terminal domain |
| Domain | IPR005482 | Biotin carboxylase, C-terminal |
| Domain | IPR011761 | ATP-grasp fold |
| Domain | IPR011764 | Biotin carboxylation domain |
| Domain | IPR041265 | Propionyl-coenzyme A carboxylase, BT domain |
| Family | IPR050856 | Biotin-dependent Carboxylase Complex |
| Homologous_superfamily | IPR011053 | Single hybrid motif |
| Homologous_superfamily | IPR011054 | Rudiment single hybrid motif |
| Homologous_superfamily | IPR013815 | ATP-grasp fold, subdomain 1 |
| Homologous_superfamily | IPR016185 | Pre-ATP-grasp domain superfamily |
Domain Details Per Protein
| Protein | Length | ATP-grasp fold | ATP-grasp fold, subdomain 1 | Biotin-binding site | Biotin carboxylase, C-terminal | Biotin carboxylase-like, N-terminal domain | Biotin carboxylation domain | Biotin-dependent Carboxylase Complex | Biotin/lipoyl attachment | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Pre-ATP-grasp domain superfamily | Propionyl-coenzyme A carboxylase, BT domain | Rudiment single hybrid motif | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DGE2
|
709 |
Interactions and Pathways
No data available
Plasmids
No data available