Gene
polr3h
- ID
- ZDB-GENE-040718-179
- Name
- polymerase (RNA) III (DNA directed) polypeptide H
- Symbol
- polr3h Nomenclature History
- Previous Names
-
- zgc:92878
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is expressed in hematopoietic system. Orthologous to human POLR3H (RNA polymerase III subunit H).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92878 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wei et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19932 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005576 | RNA polymerase Rpb7-like , N-terminal |
| Domain | IPR013238 | RNA polymerase III, subunit Rpc25 |
| Family | IPR004519 | DNA-directed RNA polymerase, subunit E/RPC8 |
| Family | IPR045113 | RNA polymerase subunit Rpb7-like |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA-directed RNA polymerase, subunit E/RPC8 | Nucleic acid-binding, OB-fold | RNA polymerase III, subunit Rpc25 | RNA polymerase Rpb7-like , N-terminal | RNA polymerase Rpb7-like, N-terminal domain superfamily | RNA polymerase subunit Rpb7-like |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DGK6 | InterPro | 214 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
polr3h-201
(1)
|
Ensembl | 1,288 nt | ||
| ncRNA |
polr3h-002
(1)
|
Ensembl | 709 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-338O16 | ||
| Encodes | cDNA | MGC:92878 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002476 (1) | 1303 nt | ||
| Genomic | GenBank:CU681842 (1) | 109310 nt | ||
| Polypeptide | UniProtKB:Q6DGK6 (1) | 214 aa |
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Wei, Y., Xu, J., Zhang, W., Wen, Z., Liu, F. (2016) RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development (Cambridge, England). 143(12):2103-10
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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