Gene

rhocb

ID
ZDB-GENE-040718-144
Name
ras homolog family member Cb
Symbol
rhocb Nomenclature History
Previous Names
  • rhoad
  • zgc:92350
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; skeletal muscle satellite cell migration; and wound healing, spreading of cells. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be located in membrane. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and neuron projection. Is expressed in dorsal aorta; intersegmental vessel; neural tube; and posterior cardinal vein. Orthologous to human RHOC (ras homolog family member C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rhocb Human Ortholog
No data available
Associated With rhocb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR001806 Small GTPase
Family IPR003578 Small GTPase Rho
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase Rho Small GTP-binding protein domain
UniProtKB:B0R1F6 94
UniProtKB:Q6DHE8 193
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Salas-Vidal et al., (2005) report orthology to human RHOA. Subsequent analysis suggests this zebrafish gene is the ortholog of human RHOC and mouse Rhoc based on amino acid identity and conserved location. A phylogenetic tree also suggests orthology to RHOC and Rhoc.
Citations