Gene

arr3a

ID

ZDB-GENE-040718-102

Name

arrestin 3a, retinal (X-arrestin)

Symbol

arr3a Nomenclature History

Previous Names

arr3l (1)
c-arrestin (1)
zgc:92697 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within visual perception. Is expressed in photopic photoreceptor cell and visual system. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ARR3 (arrestin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

30 figures from 17 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92697 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Renninger et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arr3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Myopia 26, X-linked, female-limited	301010

Associated With arr3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017864	Arrestin, conserved site
Domain	IPR011021	Arrestin-like, N-terminal
Domain	IPR011022	Arrestin C-terminal-like domain
Family	IPR000698	Arrestin
Homologous_superfamily	IPR014752	Arrestin-like, C-terminal
Homologous_superfamily	IPR014753	Arrestin, N-terminal
Homologous_superfamily	IPR014756	Immunoglobulin E-set

Domain Details Per Protein

Protein	Additional Resources	Length	Arrestin	Arrestin, conserved site	Arrestin C-terminal-like domain	Arrestin-like, C-terminal	Arrestin-like, N-terminal	Arrestin, N-terminal	Immunoglobulin E-set
UniProtKB:Q6DH07	InterPro	357

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	arr3a-201 (1) Ensembl	Ensembl		1,724 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-arr3a		arr3a		Rabbit	IHC WB		3
zpr-1	monoclonal	arr3a	IgG1 , k	Mouse	IHC	Abcam plc Zebrafish International Resource Center (ZIRC) ( order this )	379

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations