Gene
rpl11
- ID
- ZDB-GENE-040625-147
- Name
- ribosomal protein L11
- Symbol
- rpl11 Nomenclature History
- Previous Names
-
- zgc:86748
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity. Involved in several processes, including erythrocyte development; glucose homeostasis; and hemoglobin biosynthetic process. Predicted to localize to cytosolic large ribosomal subunit. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and T-cell acute lymphoblastic leukemia. Is expressed in endodermal cell; eye; intestine; liver; and pancreas. Orthologous to human RPL11 (ribosomal protein L11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 37 figures from 16 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diamond-Blackfan anemia 7 | Alliance | Diamond-Blackfan anemia 7 | 612562 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Diamond-Blackfan anemia | WT + MO1-rpl11 | standard conditions | (3) |
| Diamond-Blackfan anemia | rpl11hi3820bTg/hi3820bTg | standard conditions | (2) |
| Diamond-Blackfan anemia | rpl11hi3820bTg/hi3820bTg | standard conditions | (3) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020929 | Large ribosomal subunit protein uL5, conserved site |
| Domain | IPR031309 | Large ribosomal subunit protein uL5, C-terminal |
| Domain | IPR031310 | Large ribosomal subunit protein uL5, N-terminal |
| Family | IPR002132 | Large ribosomal subunit protein uL5 |
| Homologous_superfamily | IPR022803 | Large ribosomal subunit protein uL5 domain superfamily |
Domain Details Per Protein
| Protein | Length | Large ribosomal subunit protein uL5 | Large ribosomal subunit protein uL5, conserved site | Large ribosomal subunit protein uL5, C-terminal | Large ribosomal subunit protein uL5 domain superfamily | Large ribosomal subunit protein uL5, N-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6IQI6
|
178 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available