Gene
esrrgb
- ID
- ZDB-GENE-040616-4
- Name
- estrogen-related receptor gamma b
- Symbol
- esrrgb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable estrogen response element binding activity and nuclear receptor activity. Acts upstream of or within otic vesicle development and otolith formation. Predicted to be active in chromatin and nucleus. Orthologous to human ESRRG (estrogen related receptor gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- ay556399 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tohmé et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-esrrgb | N/A | Tohmé et al., 2014 |
| MO2-esrrgb | N/A | Tohmé et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR024178 | Estrogen receptor/oestrogen-related receptor |
| Family | IPR027289 | Oestrogen-related receptor |
| Family | IPR050200 | Nuclear hormone receptor family NR3 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Oestrogen-related receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RJ38 | InterPro | 444 | ||||||||
| UniProtKB:B3DIZ0 | InterPro | 420 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
esrrgb-201
(1)
|
Ensembl | 1,825 nt | ||
| mRNA |
esrrgb-202
(1)
|
Ensembl | 1,372 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-57I17 | ZFIN Curated Data | |
| Encodes | EST | ay556399 | (2) | |
| Encodes | cDNA | MGC:194604 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194613 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128678 (1) | 1700 nt | ||
| Genomic | GenBank:BX004824 (1) | 127755 nt | ||
| Polypeptide | UniProtKB:Q5RJ38 (1) | 444 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Makarova, K., Siudem, P., Zawada, K., Kurkowiak, J. (2016) Screening of Toxic Effects of Bisphenol A and Products of Its Degradation: Zebrafish (Danio rerio) Embryo Test and Molecular Docking. Zebrafish. 13(5):466-74
- Zhao, Y., Zhang, K., Giesy, J.P., Hu, J. (2015) Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective. Scientific Reports. 5:8554
- Tohmé, M., Prud'homme, S.M., Boulahtouf, A., Samarut, E., Brunet, F., Bernard, L., Bourguet, W., Gibert, Y., Balaguer, P., Laudet, V. (2014) Estrogen-related receptor γ is an in vivo receptor of bisphenol A. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(7):3124-3133
- Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188
- Bardet, P.L., Schubert, M., Horard, B., Holland, L.Z., Laudet, V., Holland, N.D., and Vanacker, J.M. (2005) Expression of estrogen-receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate-to-vertebrate transition. Evolution & development. 7(3):223-233
- Bardet, P.L., Obrecht-Pflumio, S., Thisse, C., Laudet, V., Thisse, B., and Vanacker, J.M. (2004) Cloning and developmental expression of five estrogen-receptor related genes in the zebrafish. Development genes and evolution. 214(5):240-249
- Bertrand, S., Brunet, F.G., Escriva, H., Parmentier, G., Laudet, V., and Robinson-Rechavi, M. (2004) Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems. Mol. Biol. Evol.. 21(10):1923-1937
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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