Gene
mos
- ID
- ZDB-GENE-040428-3
- Name
- v-mos Moloney murine sarcoma viral oncogene homolog
- Symbol
- mos Nomenclature History
- Previous Names
-
- c-mos (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Predicted to be involved in negative regulation of metaphase/anaphase transition of meiotic cell cycle; positive regulation of MAPK cascade; and signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Is expressed in blastomere and female organism. Orthologous to human MOS (MOS proto-oncogene, serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7152101 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14228 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Oocyte/zygote/embryo maturation arrest 20 | 620383 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR051681 | Serine/Threonine Kinases and Pseudokinases |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/Threonine Kinases and Pseudokinases | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90YD0 | InterPro | 329 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-24O10 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7152101 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:173909 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193946 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193952 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205580 (1) | 1241 nt | ||
| Genomic | GenBank:BX572630 (1) | 174316 nt | ||
| Polypeptide | UniProtKB:Q90YD0 (1) | 329 aa |
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Romano, S., Kaufman, O.H., Marlow, F.L. (2020) Loss of dmrt1 restores female fates in the absence of cyp19a1a but not rbpms2a/b. Development (Cambridge, England). 147(18):
- Shabnam, K.R., Gangappa, D., Philip, G.H. (2018) Zebrafish embryos exposed to deltamethrin exhibited abnormalities in spite of induced expression of related genes ( you, you-too, momo and u-boot). Toxicology and industrial health. 35(1):11-19
- Takei, N., Nakamura, T., Kawamura, S., Takada, Y., Satoh, Y., Kimura, A.P., Kotani, T. (2018) High-Sensitivity and High-Resolution In Situ Hybridization of Coding and Long Non-coding RNAs in Vertebrate Ovaries and Testes. Biological procedures online. 20:6
- Liu, D., Brewer, M.S., Chen, S., Hong, W., Zhu, Y. (2017) Transcriptomic Signatures for Ovulation in Vertebrates. General and comparative endocrinology. 247:74-86
- Horie, M., Kotani, T. (2016) Formation of mos RNA granules in the zebrafish oocyte that differ from cyclin B1 RNA granules in distribution, density and regulation. European journal of cell biology. 95(12):563-573
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Zhao, X.X., Zhang, Y.B., Ni, P.L., Wu, Z.L., Yan, Y.C., Li, Y.P. (2016) Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene. The Journal of biological chemistry. 291(1):402-12
- Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
- Takahashi, K., Kotani, T., Katsu, Y., Yamashita, M. (2014) Possible involvement of insulin-like growth factor 2 mRNA-binding protein 3 in zebrafish oocyte maturation as a novel cyclin B1 mRNA-binding protein that represses the translation in immature oocytes. Biochemical and Biophysical Research Communications. 448(1):22-7
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