Gene
ncor1
- ID
- ZDB-GENE-040426-993
- Name
- nuclear receptor corepressor 1
- Symbol
- ncor1 Nomenclature History
- Previous Names
-
- NCOR (1)
- zgc:56355
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable nuclear thyroid hormone receptor binding activity and transcription corepressor activity. Acts upstream of or within anterior/posterior pattern specification; hindbrain development; and neutrophil differentiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in chromatin. Is expressed in several structures, including epidermis; head; liver; pleuroperitoneal region; and ventricular system. Orthologous to human NCOR1 (nuclear receptor corepressor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56355 (1 image)
- MGC:56355 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025077Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2211 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13203 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13384 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17067 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17231 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18033 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20512 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38494 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38495 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ncor1 | N/A | (2) |
| MO2-ncor1 | N/A | Xu et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Myb domain | N-CoR, GPS2-interacting domain | Nuclear receptor corepressor | SANT domain | SANT/Myb domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AZS8 | InterPro | 1948 | ||||||
| UniProtKB:A0A8M3B9S7 | InterPro | 2388 | ||||||
| UniProtKB:A0A8M3ASM4 | InterPro | 1953 | ||||||
| UniProtKB:A0A8M9Q2Z1 | InterPro | 1954 | ||||||
| UniProtKB:A0A8M3B2M9 | InterPro | 2438 | ||||||
| UniProtKB:A0A8M2BCM0 | InterPro | 2411 | ||||||
| UniProtKB:A0A8M3ASH4 | InterPro | 2436 | ||||||
| UniProtKB:A0A8M3AZS6 | InterPro | 2437 | ||||||
| UniProtKB:A8B6H7 | InterPro | 2409 | ||||||
| UniProtKB:A0A8M3B2N4 | InterPro | 1949 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-202A12 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-65B12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56355 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200276 (1) | 9591 nt | ||
| Genomic | GenBank:CR848813 (1) | 206722 nt | ||
| Polypeptide | UniProtKB:A0A8M3B2M9 (1) | 2438 aa |
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Qiu, W., Liu, X., Yang, F., Li, R., Xiong, Y., Fu, C., Li, G., Liu, S., Zheng, C. (2020) Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae. The Science of the total environment. 716:137062
- Shi, B., Zhang, J., Heng, J., Gong, J., Zhang, T., Li, P., Sun, B.F., Yang, Y., Zhang, N., Zhao, Y.L., Wang, H.L., Liu, F., Zhang, Q.C., Yang, Y.G. (2020) RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Genome biology. 21:120
- Walter, K.M., Dach, K., Hayakawa, K., Giersiefer, S., Heuer, H., Lein, P.J., Fritsche, E. (2019) Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. PLoS One. 14:e0221230
- Geronikolou, S.A., Pavlopoulou, A., Kanaka-Gantenbein, C., Chrousos, G. (2018) Inter-species functional interactome of nuclear steroid receptors (R1). Frontiers in bioscience (Elite edition). 10:208-228
- Liu, H., Ma, Z., Zhang, T., Yu, N., Su, G., Giesy, J.P., Yu, H. (2018) Pharmacokinetics and effects of tetrabromobisphenol a (TBBPA) to early life stages of zebrafish (Danio rerio). Chemosphere. 190:243-252
- Walter, K.M., Miller, G.W., Chen, X., Yaghoobi, B., Puschner, B., Lein, P.J. (2018) Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). General and comparative endocrinology. 272:20-32
- den Broeder, M.J., Moester, M.J.B., Kamstra, J.H., Cenijn, P.H., Davidoiu, V., Kamminga, L.M., Ariese, F., de Boer, J.F., Legler, J. (2017) Altered Adipogenesis in Zebrafish Larvae Following High Fat Diet and Chemical Exposure Is Visualised by Stimulated Raman Scattering Microscopy. International Journal of Molecular Sciences. 18(4)
- Wu, Y., Su, G., Tang, S., Liu, W., Ma, Z., Zheng, X., Liu, H., Yu, H. (2017) The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere. 168:122-130
- Zhang, L., Jin, Y., Han, Z., Liu, H., Shi, L., Hua, X., A Doering, J., Tang, S., P Giesy, J., Yu, H. (2017) INTEGRATED IN SILICO AND IN VIVO APPROACHES TO INVESTIGATE EFFECTS OF BDE-99 MEDIATED BY THE NUCLEAR RECEPTORS ON DEVELOPING ZEBRAFISH. Environmental toxicology and chemistry. 37(3):780-787
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