Gene
h2ax
- ID
- ZDB-GENE-040426-987
- Name
- H2A.X variant histone
- Symbol
- h2ax Nomenclature History
- Previous Names
-
- H2A.X (1)
- h2afx
- zgc:56329
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of chromatin. Acts upstream of or within DNA damage response. Predicted to be located in centrosome and chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Is expressed in several structures, including brain; oocyte; proliferative region; sensory system; and unfertilized egg. Orthologous to human H2AX (H2A.X variant histone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56329 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone-fold | Histone H2A | Histone H2A conserved site | Histone H2A, C-terminal domain | Histone H2A/H2B/H3 |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUY3 | InterPro | 142 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(h2ax:EGFP-rab5c) |
|
| 1 | (12) | |
| Tg(h2ax:EGFP-rab7a) |
|
| 1 | (14) | |
| Tg(h2ax:EGFP-rab11a) |
|
| 1 | (10) | |
| Tg(h2ax:h2az2a-mCherry) |
|
| 1 | (13) | |
| Tg(h2ax:prom1b-GFP) |
|
| 1 | (2) | |
| Tg(she:h2ax-mCherry) |
|
| 1 | Peloggia et al., 2021 | |
| Tg(ubb:h2ax-EGFP-2A-mCherry-CAAX) |
| 1 | (2) | ||
| Tg(ubb:h2ax-mCherry) |
|
| 1 | Peloggia et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151N15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56329 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201073 (1) | 643 nt | ||
| Genomic | GenBank:BX294169 (1) | 73230 nt | ||
| Polypeptide | UniProtKB:Q7ZUY3 (1) | 142 aa |
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Zhu, W., Shi, Y., Zhang, C., Peng, Y., Wan, Y., Xu, Y., Liu, X., Han, B., Zhao, S., Kuang, Y., Song, H., Qiao, J. (2023) In-frame deletion of SMC5 related with the phenotype of primordial dwarfism, chromosomal instability and insulin resistance. Clinical and translational medicine. 13:e1007e1007
- Amanda, S., Tan, T.K., Ong, J.Z.L., Theardy, M.S., Wong, R.W.J., Huang, X.Z., Ali, M.Z., Li, Y., Gong, Z., Inagaki, H., Foo, E.Y., Pang, B., Tan, S.Y., Iida, S., Sanda, T. (2022) IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma. Nature communications. 13:2420
- Peloggia, J., Münch, D., Meneses-Giles, P., Romero-Carvajal, A., Lush, M.E., Lawson, N.D., McClain, M., Pan, Y.A., Piotrowski, T. (2021) Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes. Developmental Cell. 56(9):1296-1312.e7
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Chen, B., Zheng, Y.M., Zhang, M.Q., Han, Y., Zhang, J.P., Hu, C.Q. (2020) Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model. Frontiers in pharmacology. 10:1504
- Franco, J., Atieh, Y., Bryan, C.D., Kwan, K.M., Eisenhoffer, G.T. (2019) Cellular Crowding Influences Extrusion and Proliferation to Facilitate Epithelial Tissue Repair. Molecular biology of the cell. 30(16):1890-1899
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Kalka, M., Markiewicz, N., Ptak, M., Sone, E.D., Ożyhar, A., Dobryszycki, P., Wojtas, M. (2019) In vivo and in vitro analysis of starmaker activity in zebrafish otolith biomineralization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(6):6877-6886
- Turner, K.J., Hoyle, J., Valdivia, L.E., Cerveny, K.L., Hart, W., Mangoli, M., Geisler, R., Rees, M., Houart, C., Poole, R.J., Wilson, S.W., Gestri, G. (2019) Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits. PLoS One. 14:e0211073
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