Gene

hpda

ID
ZDB-GENE-040426-986
Name
4-hydroxyphenylpyruvate dioxygenase a
Symbol
hpda Nomenclature History
Previous Names
  • fb58f02
  • wu:fb58f02
  • zgc:56326
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to localize to Golgi membrane and endoplasmic reticulum membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 4 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hpda Human Ortholog
No data available
Associated With hpda Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018146 Glyoxalase I, conserved site
Domain IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
Domain IPR037523 Vicinal oxygen chelate (VOC) domain
Domain IPR041735 4-hydroxyphenylpyruvate dioxygenase, C-terminal
Domain IPR041736 4-hydroxyphenylpyruvate dioxygenase, N-terminal
Family IPR005956 4-hydroxyphenylpyruvate dioxygenase
Homologous_superfamily IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Domain Details Per Protein
Protein Length 4-hydroxyphenylpyruvate dioxygenase 4-hydroxyphenylpyruvate dioxygenase, C-terminal 4-hydroxyphenylpyruvate dioxygenase, N-terminal Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Glyoxalase/fosfomycin resistance/dioxygenase domain Glyoxalase I, conserved site Vicinal oxygen chelate (VOC) domain
UniProtKB:Q6TGZ5 397
UniProtKB:F1Q6E1 397
UniProtKB:Q7ZUY6 387
UniProtKB:A0A140LG03 127
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations