Gene

irs2a

ID
ZDB-GENE-040426-975
Name
insulin receptor substrate 2a
Symbol
irs2a Nomenclature History
Previous Names
  • zgc:56306
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Acts upstream of or within response to hypoxia. Predicted to be active in cytosol and plasma membrane. Is expressed in germ ring; head; and liver. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irs2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent} 125853
Associated With irs2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001849 Pleckstrin homology domain
Domain IPR002404 IRS-type PTB domain
Family IPR039011 Insulin receptor substrate
Homologous_superfamily IPR011993 PH-like domain superfamily
Domain Details Per Protein
Protein Length Insulin receptor substrate IRS-type PTB domain PH-like domain superfamily Pleckstrin homology domain
UniProtKB:Q7ZU74 1032
UniProtKB:F1QHL0 1032
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations