Gene
chek1
- ID
- ZDB-GENE-040426-896
- Name
- checkpoint kinase 1
- Symbol
- chek1 Nomenclature History
- Previous Names
-
- chk1 (1)
- id:ibd2720
- zgc:56093
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; mitotic G2 DNA damage checkpoint; and protein phosphorylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in forebrain; hindbrain; immature eye; and midbrain. Orthologous to human CHEK1 (checkpoint kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56093 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sidi et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Oocyte/zygote/embryo maturation arrest 21 | 620610 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR034670 | Checkpoint kinase 1, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Checkpoint kinase 1, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PQA7
|
459 | |||||
|
UniProtKB:Q7ZVD7
|
410 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available