Gene
hif1ab
- ID
- ZDB-GENE-040426-706
- Name
- hypoxia inducible factor 1 subunit alpha b
- Symbol
- hif1ab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables chromatin binding activity and transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; macrophage migration; and motor neuron axon guidance. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) UCSC scRNA-seq (1)
- Thisse Expression Data
-
- MGC:55405 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013655 | PAS fold-3 |
| Domain | IPR014887 | HIF-1 alpha, transactivation domain, C-terminal |
| Family | IPR001321 | Hypoxia-inducible factor-1 alpha |
| Family | IPR021537 | Hypoxia-inducible factor, alpha subunit |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | HIF-1 alpha, transactivation domain, C-terminal | Hypoxia-inducible factor-1 alpha | Hypoxia-inducible factor, alpha subunit | Myc-type, basic helix-loop-helix (bHLH) domain | PAC motif | PAS domain | PAS domain superfamily | PAS fold-3 |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PI33
|
533 | |||||||||
|
UniProtKB:Q6EHI4
|
777 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
hif1ab-201
(1)
|
4206 nt | |
| ncRNA |
hif1ab-002
(1)
|
686 nt | |
| ncRNA |
hif1ab-003
(1)
|
842 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-hif1ab | polyclonal | Rabbit |
|
5 |
Plasmids
No data available