Gene

hif1ab

ID

ZDB-GENE-040426-706

Name

hypoxia inducible factor 1 subunit alpha b

Symbol

hif1ab Nomenclature History

Previous Names

hif1a (1)
HIF1B (1)
wu:fb63a10 (1)
zgc:55405

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Exhibits chromatin binding activity and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including hematopoietic stem cell differentiation; macrophage migration; and motor neuron axon guidance. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in diabetic retinopathy; lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

32 figures from 24 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:55405 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hif1ab Human Ortholog

No data available

Associated With hif1ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000014	PAS domain
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR013655	PAS fold-3
Domain	IPR014887	HIF-1 alpha, transactivation domain, C-terminal
Family	IPR001321	Hypoxia-inducible factor-1 alpha
Homologous_superfamily	IPR035965	PAS domain superfamily
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily
Repeat	IPR001610	PAC motif

Domain Details Per Protein

Protein	Length	Helix-loop-helix DNA-binding domain superfamily	HIF-1 alpha, transactivation domain, C-terminal	Hypoxia-inducible factor-1 alpha	Myc-type, basic helix-loop-helix (bHLH) domain	PAC motif	PAS domain	PAS domain superfamily	PAS fold-3
UniProtKB:Q6PI33 InterPro	533
UniProtKB:Q6EHI4 InterPro	777

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	hif1ab-201 (1) Ensembl	4206 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hif1ab-002 (1) Ensembl	686 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hif1ab-003 (1) Ensembl	842 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-hif1ab	polyclonal	hif1ab		Rabbit	WB		5

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations