Gene
hif1ab
- ID
- ZDB-GENE-040426-706
- Name
- hypoxia inducible factor 1 subunit alpha b
- Symbol
- hif1ab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables chromatin binding activity and transcription cis-regulatory region binding activity. Acts upstream of or within with a positive effect on neural crest cell migration. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; macrophage migration; and motor neuron axon guidance. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55405 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR014887 | HIF-1 alpha, C-terminal transactivation domain |
| Domain | IPR021537 | Hypoxia-inducible factor, alpha subunit-like |
| Family | IPR001321 | Hypoxia-inducible factor-1 alpha |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | HIF-1 alpha, C-terminal transactivation domain | Hypoxia-inducible factor-1 alpha | Hypoxia-inducible factor, alpha subunit-like | Myc-type, basic helix-loop-helix (bHLH) domain | PAC motif | PAS domain | PAS domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6EHI4 | InterPro | 777 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hif1ab-201
(1)
|
Ensembl | 4,206 nt | ||
| ncRNA |
hif1ab-002
(1)
|
Ensembl | 686 nt | ||
| ncRNA |
hif1ab-003
(1)
|
Ensembl | 842 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-hif1ab | polyclonal | Rabbit |
|
5 |
Plasmids
No data available