Gene
ncoa4
- ID
- ZDB-GENE-040426-689
- Name
- nuclear receptor coactivator 4
- Symbol
- ncoa4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable transcription coactivator activity. Acts upstream of or within erythrocyte differentiation. Predicted to be located in several cellular components, including chromosome; cytoplasmic vesicle; and vacuole. Is expressed in digestive system and hematopoietic system. Orthologous to human NCOA4 (nuclear receptor coactivator 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77270 (1 image)
- MGC:77270 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Mancias et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027447Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ncoa4 | N/A | Mancias et al., 2015 |
| MO2-ncoa4 | N/A | Mancias et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear receptor coactivator 4 | Nuclear receptor coactivator 4, N-terminal |
|---|---|---|---|---|
| UniProtKB:Q6P0F7 | InterPro | 576 | ||
| UniProtKB:Q802X2 | InterPro | 576 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-128M15 | ZFIN Curated Data | |
| Contains | STS | chunp30254 | ||
| Encodes | EST | IMAGE:7143439 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55307 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77270 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192808 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201129 (1) | 2908 nt | ||
| Genomic | GenBank:CU019624 (2) | 179108 nt | ||
| Polypeptide | UniProtKB:Q6P0F7 (1) | 576 aa |
- Liu, Q., Song, T., Chen, B., Zhang, J., Li, W. (2023) Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22874e22874
- Wang, Y., Bo, J., Zhao, Z., Han, Y., Zhang, Q., Liu, L. (2023) Depletion of Igfbp7 alleviates zebrafish NAFLD progression through inhibiting hepatic ferroptosis. Life sciences. 332:122086
- Xie, X., Jin, Y., Ma, Z., Tang, S., Peng, H., Giesy, J.P., Liu, H. (2019) Underlying mechanisms of reproductive toxicity caused by multigenerational exposure of 2, bromo-4, 6-dinitroaniline (BDNA) to Zebrafish (Danio rerio) at environmental relevant levels. Aquatic toxicology (Amsterdam, Netherlands). 216:105285
- Liu, H., Ma, Z., Zhang, T., Yu, N., Su, G., Giesy, J.P., Yu, H. (2018) Pharmacokinetics and effects of tetrabromobisphenol a (TBBPA) to early life stages of zebrafish (Danio rerio). Chemosphere. 190:243-252
- Wu, Y., Su, G., Tang, S., Liu, W., Ma, Z., Zheng, X., Liu, H., Yu, H. (2017) The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere. 168:122-130
- Zhang, L., Jin, Y., Han, Z., Liu, H., Shi, L., Hua, X., A Doering, J., Tang, S., P Giesy, J., Yu, H. (2017) INTEGRATED IN SILICO AND IN VIVO APPROACHES TO INVESTIGATE EFFECTS OF BDE-99 MEDIATED BY THE NUCLEAR RECEPTORS ON DEVELOPING ZEBRAFISH. Environmental toxicology and chemistry. 37(3):780-787
- Li, Z., Long, Y., Zhong, L., Song, G., Zhang, X., Yuan, L., Cui, Z., Dai, H. (2016) RNA sequencing provides insights into the toxicogenomic response of ZF4 cells to methyl methanesulfonate. Journal of applied toxicology : JAT. 36(1):94-104
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, H., Tang, S., Zheng, X., Zhu, Y., Ma, Z., Liu, C., Hecker, M., Saunders, D.M., Giesy, J.P., Zhang, X., Yu, H. (2015) Bioaccumulation, biotransformation and toxicity of BDE-47, 6-OH-BDE-47 and 6-MeO-BDE-47 in early life-stages of zebrafish (Danio rerio). Environmental science & technology. 49(3):1823-33
- Long, Y., Yan, J., Song, G., Li, X., Li, X., Li, Q., Cui, Z. (2015) Transcriptional events co-regulated by hypoxia and cold stresses in Zebrafish larvae. BMC Genomics. 16:385
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