Gene
hdac8
- ID
- ZDB-GENE-040426-2772
- Name
- histone deacetylase 8
- Symbol
- hdac8 Nomenclature History
- Previous Names
-
- wu:fd19a02
- zgc:66196 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable histone deacetylase activity and histone decrotonylase activity. Acts upstream of or within central nervous system development and neuron cellular homeostasis. Predicted to be located in several cellular components, including chromosome; nucleus; and plasma membrane. Is expressed in several structures, including brain; fin bud; gut; muscle; and oocyte. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144626 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cornelia de Lange syndrome 5 | Alliance | Cornelia de Lange syndrome 5 | 300882 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Cornelia de Lange syndrome | AB + MO2-hdac8 | standard conditions | Bottai et al., 2018 |
| Cornelia de Lange syndrome | AB + MO3-hdac8 | standard conditions | Bottai et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011613 | GH15-like domain |
| Domain | IPR023801 | Histone deacetylase domain |
| Domain | IPR045583 | Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain |
| Family | IPR000286 | Histone deacetylase family |
| Family | IPR003084 | Histone deacetylase |
| Family | IPR008734 | Phosphorylase kinase alpha/beta subunit |
| Family | IPR050284 | Histone deacetylase and polyamine deacetylase |
| Homologous_superfamily | IPR008928 | Six-hairpin glycosidase superfamily |
| Homologous_superfamily | IPR012341 | Six-hairpin glycosidase-like superfamily |
| Homologous_superfamily | IPR023696 | Ureohydrolase domain superfamily |
| Homologous_superfamily | IPR037138 | Histone deacetylase domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | GH15-like domain | Histone deacetylase | Histone deacetylase and polyamine deacetylase | Histone deacetylase domain | Histone deacetylase domain superfamily | Histone deacetylase family | Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain | Phosphorylase kinase alpha/beta subunit | Six-hairpin glycosidase-like superfamily | Six-hairpin glycosidase superfamily | Ureohydrolase domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXM0 | InterPro | 378 | |||||||||||
| UniProtKB:A0A8M2BE34 | InterPro | 311 | |||||||||||
| UniProtKB:A0A286YAZ5 | InterPro | 1232 | |||||||||||
| UniProtKB:E7F4R5 | InterPro | 1219 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-hdac8 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
4 |
Plasmids
No data available