Gene

map2k1

ID
ZDB-GENE-040426-2759
Name
mitogen-activated protein kinase kinase 1
Symbol
map2k1 Nomenclature History
Previous Names
  • mek1 (1)
  • si:ch211-242m18.2
  • wu:fj56a12
  • wu:fj61b01 (1)
  • zgc:56557
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have MAP kinase kinase activity. Predicted to be involved in activation of MAPK activity. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in bone disease (multiple); carcinoma (multiple); and cardiofaciocutaneous syndrome 3. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With map2k1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cardiofaciocutaneous syndrome 3 615279
Melorheostosis, isolated, somatic mosaic 155950
Associated With map2k1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q4V947 395
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA map2k1-201 (1) Havana 2093 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations