Gene

ddc

ID
ZDB-GENE-040426-2656
Name
dopa decarboxylase
Symbol
ddc Nomenclature History
Previous Names
  • aromatic amino acid decarboxylase (1)
  • wu:fa56d05
  • wu:fd59h03
  • wu:fk20h01
  • zgc:65801 (1)
  • zgc:76929 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have aromatic-L-amino-acid decarboxylase activity. Involved in brain development. Predicted to localize to cytoplasm. Is expressed in digestive system; muscle; nervous system; ovary; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase).
Genome Resources
Note
None
Expression
All Expression Data
16 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Shih et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ddc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aromatic L-amino acid decarboxylase deficiency Alliance Aromatic L-amino acid decarboxylase deficiency 608643
Associated With ddc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021115 Pyridoxal-phosphate binding site
Family IPR002129 Pyridoxal phosphate-dependent decarboxylase
Family IPR010977 Aromatic-L-amino-acid decarboxylase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase domain 1
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Aromatic-L-amino-acid decarboxylase Pyridoxal-phosphate binding site Pyridoxal phosphate-dependent decarboxylase Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase domain 1 Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:Q7SZR0 480
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations