Gene
rhcgb
- ID
- ZDB-GENE-040426-2595
- Name
- Rh family, C glycoprotein b
- Symbol
- rhcgb Nomenclature History
- Previous Names
-
- rhcg
- rhcgl2
- drRhcg1 (1)
- zgc:77520
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable ammonium channel activity. Acts upstream of or within ammonium homeostasis and ammonium transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in gill; immune system; integument; and yolk. Orthologous to human RHCG (Rh family C glycoprotein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77520 (2 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ammonium transporter AmtB-like domain | Ammonium/urea transporter | Blood group Rhesus C/E/D polypeptide |
|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z506 | InterPro | 478 | |||
| UniProtKB:A0A0R4IBV5 | InterPro | 488 | |||
| UniProtKB:Q8JI14 | InterPro | 488 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
- Wang, Y., Pasparakis, C., Grosell, M. (2021) Role of the cardiovascular system in ammonia excretion in early life stages of zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 321(3):R377-R384
- Lee, C.Y., Horng, J.L., Liu, S.T., Lin, L.Y. (2020) Exposure to copper nanoparticles impairs ion uptake, and acid and ammonia excretion by ionocytes in zebrafish embryos. Chemosphere. 261:128051
- Porteus, C., Kumai, Y., Abdallah, S.J., Yew, H.M., Kwong, R.W.M., Pan, Y., Milsom, W.K., Perry, S.F. (2020) Respiratory responses to external ammonia in zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 251:110822
- Shir-Mohammadi, K., Perry, S.F. (2020) Expression of ion-transport genes in ionocytes isolated from larval zebrafish (Danio rerio) exposed to acidic or Na+ deficient water. American journal of physiology. Regulatory, integrative and comparative physiology. 319(4):R412-R427
- Zimmer, A.M., Perry, S.F. (2020) The Rhesus glycoprotein Rhcgb is expendable for ammonia excretion and Na+ uptake in zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 247:110722
- Zimmer, A.M., Shir-Mohammadi, K., Kwong, R.W.M., Perry, S.F. (2020) Reassessing the contribution of the Na+/H+ exchanger Nhe3b to Na+ uptake in zebrafish (Danio rerio) using CRISPR/Cas9 gene editing. The Journal of experimental biology. 223(Pt 2)
- Fu, J., Tan, Y.X.R., Gong, Z., Bae, S. (2019) The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos. Ecotoxicology and environmental safety. 189:110039
- Chatzopoulou, A., Schoonheim, P.J., Torraca, V., Meijer, A.H., Spaink, H.P., Schaaf, M.J. (2017) Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish. Molecular and Cellular Endocrinology. 447:61-70
- Aceto, J., Nourizadeh-Lillabadi, R., Marée, R., Dardenne, N., Jeanray, N., Wehenkel, L., Aleström, P., van Loon, J.J., Muller, M. (2015) Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity. PLoS One. 10:e0126928
- Chatzopoulou, A., Roy, U., Meijer, A.H., Alia, A., Spaink, H.P., Schaaf, M.J. (2015) Transcriptional and Metabolic Effects of Glucocorticoid Receptor α and β Signaling in Zebrafish. Endocrinology. 156(5):1757-69
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