Gene
cdipt
- ID
- ZDB-GENE-040426-2536
- Name
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
- Symbol
- cdipt Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity. Acts upstream of or within several processes, including camera-type eye development; endoplasmic reticulum tubular network maintenance; and intestinal epithelial structure maintenance. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in brain; digestive system; eye; and fin. Used to study steatotic liver disease. Orthologous to human CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 32 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi559Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hsc158 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| la010472Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la010730Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023981Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nt9 | Allele with one point mutation | Exon 3 | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdipt | Smith et al., 2020 | |
| MO1-cdipt | N/A | Murphy et al., 2011 |
| MO2-cdipt | N/A | Murphy et al., 2011 |
| MO3-cdipt | N/A | (2) |
| MO4-cdipt | N/A | Thakur et al., 2011 |
| MO5-cdipt | N/A | (2) |
| MO6-cdipt | N/A | Smith et al., 2020 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| steatotic liver disease | cdipthi559Tg/hi559Tg | standard conditions | (2) |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR048254 | CDP-alcohol phosphatidyltransferase, conserved site |
| Family | IPR000462 | CDP-alcohol phosphatidyltransferase |
| Family | IPR014387 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote |
| Homologous_superfamily | IPR043130 | CDP-alcohol phosphatidyltransferase, transmembrane domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CDP-alcohol phosphatidyltransferase | CDP-alcohol phosphatidyltransferase, conserved site | CDP-alcohol phosphatidyltransferase, transmembrane domain | CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NYP5 | InterPro | 213 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-183N6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77540 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174794 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_207088 (1) | 1527 nt | ||
| Genomic | GenBank:CR387996 (1) | 210145 nt | ||
| Polypeptide | UniProtKB:Q6NYP5 (1) | 213 aa |
- Smith, L., Fabian, L., Al-Maawali, A., Noche, R.R., Dowling, J.J. (2020) De novo phosphoinositide synthesis in zebrafish is required for triad formation but not essential for myogenesis. PLoS One. 15:e0231364
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- McCammon, J.M., Blaker-Lee, A., Chen, X., Sive, H. (2017) The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human molecular genetics. 26:3699-3712
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Thakur, P.C., Davison, J.M., Stuckenholz, C., Lu, L., and Bahary, N. (2014) Dysregulated phosphatidylinositol signaling promotes endoplasmic reticulum stress-mediated intestinal mucosal injury and inflammation in zebrafish. Disease models & mechanisms. 7(1):93-106
- Asaoka, Y., Terai, S., Sakaida, I., and Nishina, H. (2013) The expanding role of fish models in understanding non-alcoholic fatty liver disease. Disease models & mechanisms. 6(4):905-914
- Nguyen, M., Yang, E., Neelkantan, N., Mikhaylova, A., Arnold, R., Poudel, M.K., Stewart, A.M., and Kalueff, A.V. (2013) Developing 'integrative' zebrafish models of behavioral and metabolic disorders. Behavioural brain research. 256C:172-187
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Blaker-Lee, A., Gupta, S., McCammon, J.M., De Rienzo, G., and Sive, H. (2012) Zebrafish homologs of 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Disease models & mechanisms. 5(6):834-851
- Murphy, T.R., Vihtelic, T.S., Ile, K.E., Watson, C.T., Willer, G.B., Gregg, R.G., Bankaitis, V.A., and Hyde, D.R. (2011) Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye. Experimental Eye Research. 93(4):460-74
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