Gene

amfra

ID

ZDB-GENE-040426-2190

Name

autocrine motility factor receptor a

Symbol

amfra Nomenclature History

Previous Names

amfr
wu:fi06e06
wu:fi37e05
zgc:63893 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Exhibits ubiquitin protein ligase activity. Involved in protein polyubiquitination and response to endoplasmic reticulum stress. Localizes to endoplasmic reticulum. Is expressed in brain; digestive system; eye; heart; and muscle. Orthologous to human AMFR (autocrine motility factor receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63893 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With amfra Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary spastic paraplegia 89	Alliance	Spastic paraplegia 89, autosomal recessive	620379

Associated With amfra Via Experimental Models

Human Disease	Fish	Conditions	Citations
hereditary spastic paraplegia	amfra^re31/re31	standard conditions	Deng et al., 2023

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR003892	Ubiquitin system component CUE
Domain	IPR040675	E3 ubiquitin-protein ligase AMFR, Ube2g2-binding region
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type