Gene

otulina

ID

ZDB-GENE-040426-2157

Name

OTU deubiquitinase with linear linkage specificity a

Symbol

otulina Nomenclature History

Previous Names

fam105ba
wu:fj43e01
zgc:64095

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein linear deubiquitination. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in alar plate midbrain region; lens; optic tectum; retina; and solid lens vesicle. Human ortholog(s) of this gene implicated in otulipenia and primary immunodeficiency disease. Orthologous to several human genes including OTULIN (OTU deubiquitinase with linear linkage specificity).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64095 (4 images)
IMAGE:6909406 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Cheung et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With otulina Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
otulipenia	Alliance	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive	617099
		Autoinflammation, panniculitis, and dermatosis syndrome, autosomal dominant	621030
		{Immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection}	619986

Associated With otulina Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR019191	Essential protein Yae1, N-terminal
Family	IPR038881	Yae1-like

Domain Details Per Protein

Protein	Length	Essential protein Yae1, N-terminal	Yae1-like
UniProtKB:Q7T354 InterPro	220

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	otulina-205 (1) Ensembl	Ensembl	931 nt	Select Tool ZFIN BLAST
mRNA	otulina-201 (1) Ensembl	Ensembl	1,268 nt	Select Tool ZFIN BLAST
mRNA	otulina-202 (1) Ensembl	Ensembl	535 nt	Select Tool ZFIN BLAST
mRNA	otulina-204 (1) Ensembl	Ensembl	3,081 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations