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ZIRC
ZFIN ID: ZDB-GENE-040426-2039
Gene Name: ubiquitin-like with PHD and ring finger domains 1
Gene Symbol: uhrf1    Nomenclature History

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Previous Names: fb97f09, NP95 (1), unm b1115, unm_b1115, wu:fb97f09, zgc:63539

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have several functions, including hemi-methylated DNA-binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Involved in several processes, including animal organ development; hypermethylation of CpG island; and intestinal epithelial structure maintenance. Predicted to localize to the euchromatin; nuclear heterochromatin; and replication fork. Is expressed in several structures, including brain; eye; liver; pleuroperitoneal region; and presumptive neural retina. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1).
Genome Resources: Alliance (1),  Gene:406350 (1),  Ensembl(GRCz11):ENSDARG00000103409 (1)
Note:
GENE EXPRESSION
All Expression Data: 7 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63539]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1115 Point Mutation Unknown Unknown ENU
hi272Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi3020Tg Transgenic Insertion Intron 1 Unknown DNA
    pd1092 Point Mutation Donor Splice Site of Exon 5 Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-uhrf1 N/A 4
    MO2-uhrf1 N/A 1
    MO3-uhrf1 N/A 1
    DISEASE ASSOCIATED WITH uhrf1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH uhrf1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process inflammatory response (more)
    Cellular Component euchromatin (more)
    Molecular Function hemi-methylated DNA-binding (more)
    GO Terms (all 29)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA uhrf1-201 (1)    Ensembl 5079
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-uhrf1 polyclonal Rabbit WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM uhrf1 No data available
    MARKER RELATIONSHIPS
    uhrf1 Contained in: [BAC] CH211-124A3 (1) (order this)
    uhrf1 Encodes: [EST] fb97f09
    [cDNA] MGC:63539 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213077 (1) 5099 bp
    Genomic GenBank:BX927276 (1) 166844 bp
    Select Tool
    Polypeptide UniProtKB:E7EZF3 (1) 776 aa
    Sequence Clusters UniGene:77703 (1)
    Sequence Information (all 13)
    ORTHOLOGY for uhrf1 ( Chr: 22 )
    CITATIONS (47)