Gene

chchd10

ID

ZDB-GENE-040426-1753

Name

coiled-coil-helix-coiled-coil-helix domain containing 10

Symbol

chchd10 Nomenclature History

Previous Names

chchd2
zgc:73308

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Involved in axonogenesis and skeletal myofibril assembly. Predicted to localize to mitochondrion and nucleus. Human ortholog(s) of this gene implicated in FTDALS2. Is expressed in several structures, including adaxial cell; alar plate midbrain region; digestive system; musculature system; and optic vesicle. Orthologous to human CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73308 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Brockmann et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chchd10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
frontotemporal dementia and/or amyotrophic lateral sclerosis 2	Alliance	Frontotemporal dementia and/or amyotrophic lateral sclerosis 2	615911
isolated mitochondrial myopathy	Alliance	?Myopathy, isolated mitochondrial, autosomal dominant	616209
spinal muscular atrophy, Jokela type	Alliance	Spinal muscular atrophy, Jokela type	615048

Associated With chchd10 Via Experimental Models

Human Disease	Fish	Conditions	Citations
motor neuron disease	WT + MO1-chchd10	standard conditions	Brockmann et al., 2018
motor neuron disease	WT + MO2-chchd10	standard conditions	Brockmann et al., 2018