Gene

pde6c

ID

ZDB-GENE-040426-1664

Name

phosphodiesterase 6C, cGMP-specific, cone, alpha prime

Symbol

pde6c Nomenclature History

Previous Names

eclipse (1)
pde6 alpha prime (1)
zgc:73085

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have 3',5'-cyclic-nucleotide phosphodiesterase activity and metal ion binding activity. Involved in embryonic retina morphogenesis in camera-type eye; photoreceptor cell maintenance; and visual perception. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Is expressed in head and visual system. Orthologous to human PDE6C (phosphodiesterase 6C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pde6c Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cone dystrophy 4	613093

Associated With pde6c Via Experimental Models

Human Disease	Fish	Conditions	Citations
retinal degeneration	pde6c^w59/w59	standard conditions	(3)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain	IPR003018	GAF domain
Domain	IPR003607	HD/PDEase domain
Family	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily	IPR029016	GAF-like domain superfamily
Homologous_superfamily	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily